Human SYT4 Recombinant Protein (RPPB4889)

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SKU:
RPPB4889
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SYT4
Synonyms:
HsT1192
Synonyms:
KIAA1342
Synonyms:
Synaptotagmin-4
Synonyms:
Synaptotagmin IV
Source:
Escherichia Coli
Uniprot:
Q9H2B2
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Description

Product Name:Human SYT4 Recombinant Protein
Product Code:RPPB4889
Size:10µg
Species:Human
Target:SYT4
Synonyms:HsT1192, KIAA1342, Synaptotagmin-4, Synaptotagmin IV, SytIV, SYT4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SYT4 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MCQRKSSKSN KTPPYKFVHV LKGVDIYPEN LNSKKKFGAD DKNEVKNKPA VPKNSLHLDL EKRDLNGNFP KTNLKPGSPS DLENATPKLF LEGEKESVSP ESLKSSTSLT SEEKQEKLGT LFFSLEYNFE RKAFVVNIKE ARGLPAMDEQ SMTSDPYIKM TILPEKKHKV KTRVLRKTLD PAFDETFTFY GIPYTQIQEL ALHFTILSFD RFSRDDIIGE VLIPLSGIEL SEGKMLMNRE IIKRNVRKSS GRGELLISLC YQSTTNTLTV VVLKARHLPK SDVSGLSDPY VKVNLYHAKK RISKKKTHVK KCTPNAVFNE LFVFDIPCEG LEDISVEFLV LDSERGSRNE VIGQLVLGAA AEGTGGEHWK EICDYPRRQI AKWHVLCDG

Synaptotagmin-4 (SYT4) is a part of the synaptotagmin proteins family. Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that operate as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. SYT4 is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus. The proximity of the SYT4 gene to markers of several psychiatric disorders implies an involvement of SYT4 in human disease such as pheochromocytoma, and parkinson's disease.

SYT4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 409 amino acids (38-425a.a) and having a molecular mass of 46.1kDa. SYT4 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SYT4: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Belongs to the synaptotagmin family.
UniProt Protein Details:

Protein type:Calcium-binding; Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 18q12.3

Cellular Component: intracellular membrane-bound organelle; plasma membrane

Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; protein binding; syntaxin binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; regulation of calcium ion-dependent exocytosis; vesicle fusion

UniProt Code:Q9H2B2
NCBI GenInfo Identifier:18202937
NCBI Gene ID:6860
NCBI Accession:Q9H2B2.1
UniProt Secondary Accession:Q9H2B2,Q9P2K4, B4DEU3,
UniProt Related Accession:Q9H2B2
Molecular Weight:46,064 Da
NCBI Full Name:Synaptotagmin-4
NCBI Synonym Full Names:synaptotagmin 4
NCBI Official Symbol:SYT4  
NCBI Official Synonym Symbols:HsT1192  
NCBI Protein Information:synaptotagmin-4
UniProt Protein Name:Synaptotagmin-4
UniProt Synonym Protein Names:Synaptotagmin IV; SytIV
Protein Family:Synaptotagmin
UniProt Gene Name:SYT4  
UniProt Entry Name:SYT4_HUMAN
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