Human SYCE3 Recombinant Protein (RPPB4884)

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SKU:
RPPB4884
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SYCE3
Synonyms:
Synaptonemal complex central element protein 3
Synonyms:
chromosome 22 open reading frame 41
Synonyms:
Testis highly expressed gene 2 protein
Synonyms:
testis highly expressed protein 2
Source:
Escherichia Coli
Uniprot:
A1L190
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Description

Product Name:Human SYCE3 Recombinant Protein
Product Code:RPPB4884
Size:10µg
Species:Human
Target:SYCE3
Synonyms:Synaptonemal complex central element protein 3, chromosome 22 open reading frame 41, Testis highly expressed gene 2 protein, testis highly expressed protein 2, THEG2, C22orf41.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The SYCE3 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MDDADPEERN YDNMLKMLSD LNKDLEKLLE EMEKISVQAT WMAYDMVVMR TNPTLAESMR RLEDAFVNCK EEMEKNWQEL LHETKQRL

Synaptonemal complex central element protein 3 (SYCE3) is key component of the transverse central element of synaptonemal complexes (SCS). The synaptonemal complex is a protein structure which forms between homologous chromosomes (2 pairs of sister chromatids) during meiosis and is assumed to mediate chromosome pairing, synapsis, and recombination (crossing-over). The SYCE3 protein is essential for chromosome loading of the central element-specific SCS proteins, as well as for initiating synapsis between homologous chromosomes. SYCE3 is also vital for fertility.

SYCE3 Human Recombinant produced in E. coli is a single polypeptide chain containing 108 amino acids (1-88) and having a molecular mass of 12.8 kDa.SYCE3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SYCE3: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility.Chromosomal Location of Human Ortholog: 22q13.33Cellular Component: central element; chromosome; nucleusBiological Process: synaptonemal complex assembly; cell division; positive regulation of apoptosis; meiotic recombination; spermatogenesis
UniProt Protein Details:
NCBI Summary:
UniProt Code:A1L190
NCBI GenInfo Identifier:178557813
NCBI Gene ID:644186
NCBI Accession:NP_001116697.1
UniProt Secondary Accession:A1L190
UniProt Related Accession:A1L190
Molecular Weight:10,601 Da
NCBI Full Name:synaptonemal complex central element protein 3
NCBI Synonym Full Names:synaptonemal complex central element protein 3
NCBI Official Symbol:SYCE3  
NCBI Official Synonym Symbols:THEG2; C22orf41  
NCBI Protein Information:synaptonemal complex central element protein 3; testis highly expressed gene 2 protein; testis highly expressed protein 2
UniProt Protein Name:Synaptonemal complex central element protein 3
UniProt Synonym Protein Names:Testis highly expressed gene 2 protein; THEG-2
Protein Family:Synaptonemal complex central element protein
UniProt Gene Name:SYCE3  
UniProt Entry Name:SYCE3_HUMAN
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