Human STX12 Recombinant Protein (RPPB4863)
- SKU:
- RPPB4863
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- STX12
- Synonyms:
- Syntaxin 12
- STX13
- STX14
- Source:
- Escherichia Coli
- Uniprot:
- Q86Y82
Description
| Product Name: | Human STX12 Recombinant Protein |
| Product Code: | RPPB4863 |
| Size: | 10µg |
| Species: | Human |
| Target: | STX12 |
| Synonyms: | Syntaxin 12, STX13, STX14. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The STX12 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 1mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSYGPL DMYRNPGPSG PQLRDFSSII QTCSGNIQRI SQATAQIKNL MSQLGTKQDS SKLQENLQQL QHSTNQLAKE TNELLKELGS LPLPLSTSEQ RQQRLQKERL MNDFSAALNN FQAVQRRVSE KEKESIARAR AGSRLSAEER QREEQLVSFD SHEEWNQMQS QEDEVAITEQ DLELIKERET AIRQLEADIL DVNQIFKDLA MMIHDQGDLI DSIEANVESS EVHVERATEQ LQRAAYYQKK SR |
STX12 is a member of the syntaxin family which are cellular receptors for transport of vesicles that take part in exocytosis in neutrophils. STX12 regulates protein transport from late endosomes and the trans-Golgi network and back. Additionally, STX12 cooperates with ABC1 (ATP-binding cassette transporter A1), which enables cellular release of cholesterol and choline-phospholipids to apoA-I (apolipoprotein A-I).
STX12 Human Recombinant produced in E. coli is a single polypeptide chain containing 272 amino acids (1-248) and having a molecular mass of 31.0kDa.STX12 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | STX12: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro). Belongs to the syntaxin family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle Chromosomal Location of Human Ortholog: 1p35.3 Cellular Component: endomembrane system; integral to membrane; lipid raft; phagocytic vesicle; SNARE complex; vesicle Molecular Function:protein binding; SNAP receptor activity; SNARE binding Biological Process: autophagic vacuole formation; cholesterol efflux; intracellular protein transport; protein stabilization; vesicle docking; vesicle fusion |
| UniProt Code: | Q86Y82 |
| NCBI GenInfo Identifier: | 47117211 |
| NCBI Gene ID: | 23673 |
| NCBI Accession: | Q86Y82.1 |
| UniProt Secondary Accession: | Q86Y82,O95564, B1AJQ7, |
| UniProt Related Accession: | Q86Y82 |
| Molecular Weight: | 31,642 Da |
| NCBI Full Name: | Syntaxin-12 |
| NCBI Synonym Full Names: | syntaxin 12 |
| NCBI Official Symbol: | STX12 |
| NCBI Official Synonym Symbols: | STX13; STX14 |
| NCBI Protein Information: | syntaxin-12 |
| UniProt Protein Name: | Syntaxin-12 |
| Protein Family: | Syntaxin |
| UniProt Gene Name: | STX12 |
| UniProt Entry Name: | STX12_HUMAN |
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