Human STX11 Recombinant Protein (RPPB4862)

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SKU:
RPPB4862
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
STX11
Synonyms:
Syntaxin-11
Synonyms:
STX11
Synonyms:
FHL4
Synonyms:
HLH4
Source:
Escherichia Coli
Uniprot:
O75558
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Description

Product Name:Human STX11 Recombinant Protein
Product Code:RPPB4862
Size:20µg
Species:Human
Target:STX11
Synonyms:Syntaxin-11, STX11, FHL4, HLH4, HPLH4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:STX11 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMKDRLA ELLDLSKQYD QQFPDGDDEF DSPHEDIVFE TDHILESLYR DIRDIQDENQ LLVADVKRLG KQNARFLTSM RRLSSIKRDT NSIAKAIKAR GEVIHCKLRA MKELSEAAEA QHGPHSAVAR ISRAQYNALT LTFQRAMHDY NQAEMKQRDN CKIRIQRQLE IMGKEVSGDQ IEDMFEQGKW DVFSENLLAD VKGARAALNE IESRHRELLR LESRIRDVHE LFLQMAVLVE KQADTLNVIE LNVQKTVDYT GQAKAQVRKA VQYEEKNPCR TLCCFCCPCL K

Syntaxin-11 (STX11) belongs to the t-SNARE family. Syntaxin-11 regulates protein transport between late endosomes and the trans-Golgi network. STX11 interacts with the SNARE proteins SNAP-23 and VAMP. STX11 gene mutations are linked with familial hemophagocytic lymphohistiocytosis.

STX11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 311 amino acids (1-287 a.a) and having a molecular mass of 35.8kDa.STX11 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:STX11: SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. Defects in STX11 are the cause of familial hemophagocytic lymphohistiocytosis type 4 (FHL4); also known as HPLH4. Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous, rare autosomal recessive disorder. It is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, and neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits, and ataxia. Hemophagocytosis is a prominent feature of the disease, and a non-malignant infiltration of macrophages and activated T-lymphocytes in lymph nodes, spleen, and other organs is also found. Belongs to the syntaxin family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 6q24.2

Cellular Component: integral to membrane; plasma membrane; SNARE complex; synaptic vesicle

Molecular Function:protein binding; SNARE binding

Biological Process: intracellular protein transport; synaptic vesicle fusion to presynaptic membrane; vesicle docking

Disease: Hemophagocytic Lymphohistiocytosis, Familial, 4

NCBI Summary:This gene encodes a member of the syntaxin family. Syntaxins have been implicated in the targeting and fusion of intracellular transport vesicles. This family member may regulate protein transport among late endosomes and the trans-Golgi network. Mutations in this gene have been associated with familial hemophagocytic lymphohistiocytosis. [provided by RefSeq, Jul 2008]
UniProt Code:O75558
NCBI GenInfo Identifier:6175047
NCBI Gene ID:8676
NCBI Accession:O75558.1
UniProt Secondary Accession:O75558,O75378, O95148, Q5TCL6, E1P598,
UniProt Related Accession:O75558
Molecular Weight:33,196 Da
NCBI Full Name:Syntaxin-11
NCBI Synonym Full Names:syntaxin 11
NCBI Official Symbol:STX11  
NCBI Official Synonym Symbols:FHL4; HLH4; HPLH4  
NCBI Protein Information:syntaxin-11
UniProt Protein Name:Syntaxin-11
Protein Family:Syntaxin
UniProt Gene Name:STX11  
UniProt Entry Name:STX11_HUMAN
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