Human STIP1 Recombinant Protein (RPPB4847)

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SKU:
RPPB4847
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
STIP1
Synonyms:
Stress Induced Phosphoprotein 1
Synonyms:
Transformation-SensitiveProtein IEF SSP 3521
Synonyms:
Renal Carcinoma Antigen NY-REN-11
Synonyms:
Stress-Induced-Phosphoprotein 1
Source:
Escherichia Coli
Uniprot:
P31948
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Description

Product Name:Human STIP1 Recombinant Protein
Product Code:RPPB4847
Size:25µg
Species:Human
Target:STIP1
Synonyms:Stress Induced Phosphoprotein 1, Transformation-SensitiveProtein IEF SSP 3521, Renal Carcinoma Antigen NY-REN-11,Stress-Induced-Phosphoprotein 1, Hsp70/Hsp90-Organizing Protein,Hsc70/Hsp90-Organizing Protein, STI1, HOP, Epididymis Secretory Sperm BindingProtein Li 94n, NY-REN-11 Antigen, IEF-SSP-3521, HEL-S-94n, STI1L, P60.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:STIP1 protein solution (0.5mg/ml) containing 20mMTris-HCl (pH 8.0), 10% glycerol, 1mM DTT and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MEQVNELKEK GNKALSVGNI DDALQCYSEA IKLDPHNHVL YSNRSAAYAKKGDYQKAYED GCKTVDLKPD WGKGYSRKAA ALEFLNRFEE AKRTYEEGLK HEANNPQLKE GLQNMEARLAERKFMNPFNM PNLYQKLESD PRTRTLLSDP TYRELIEQLR NKPSDLGTKL QDPRIMTTLS VLLGVDLGSMDEEEEIATPP PPPPPKKETK PEPMEEDLPE NKKQALKEKE LGNDAYKKKD FDTALKHYDK AKELDPTNMTYITNQAAVYF EKGDYNKCRE LCEKAIEVGR ENREDYRQIA KAYARIGNSY FKEEKYKDAI HFYNKSLAEHRTPDVLKKCQ QAEKILKEQE RLAYINPDLA LEEKNKGNEC FQKGDYPQAM KHYTEAIKRN PKDAKLYSNRAACYTKLLEF QLALKDCEEC IQLEPTFIKG YTRKAAALEA MKDYTKAMDV YQKALDLDSS CKEAADGYQRCMMAQYNRHD SPEDVKRRAM ADPEVQQIMS DPAMRLILEQ MQKDPQALSE HLKNPVIAQK IQKLMDVGLI AIR

STIP1 is an adaptor protein that mediates the functions of HSP70 & HSP90 in protein folding. STIP1 supports the transfer of proteins from HSP70 to HSP90 by binding together HSP90 and substrate-bound HSP70. STIP1 stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones. STIP1 genetic variations are involved in regulating corticosteroid response in asthmatic subjects with reduced lung function.

STIP1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 543 amino acids (1-543 a.a) andhaving a molecular mass of 62.6kDa. STIP1 is purified by proprietary chromatographictechniques.

UniProt Protein Function:STI1: a protein that is apparently involved in the response to stress. Specifically interacts with the C-terminal tails of Hsp70 and Hsp90 via TPR1 and TPR2A domains. Deletion of STI1 reduces the activity of the glucocorticoid receptor, a Hsp90 target protein. Phosphorylated in vitro by p90RSK and casein kinase II.
UniProt Protein Details:

Protein type:Chaperone

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi apparatus; nucleus

Molecular Function:protein binding

Biological Process: response to stress

NCBI Summary:STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
UniProt Code:P31948
NCBI GenInfo Identifier:400042
NCBI Gene ID:10963
NCBI Accession:P31948.1
UniProt Secondary Accession:P31948,Q3ZCU9, Q5TZU9, B4DM70, F5H0T1, G3XAD8,
UniProt Related Accession:P31948
Molecular Weight:543
NCBI Full Name:Stress-induced-phosphoprotein 1
NCBI Synonym Full Names:stress-induced phosphoprotein 1
NCBI Official Symbol:STIP1  
NCBI Official Synonym Symbols:HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521  
NCBI Protein Information:stress-induced-phosphoprotein 1; NY-REN-11 antigen; Hsp70/Hsp90-organizing protein; hsc70/Hsp90-organizing protein; renal carcinoma antigen NY-REN-11; transformation-sensitive protein IEF SSP 3521; epididymis secretory sperm binding protein Li 94n
UniProt Protein Name:Stress-induced-phosphoprotein 1
UniProt Synonym Protein Names:Hsc70/Hsp90-organizing protein; Hop; Renal carcinoma antigen NY-REN-11; Transformation-sensitive protein IEF SSP 3521
Protein Family:STIP1 homology and U box-containing protein
UniProt Gene Name:STIP1  
UniProt Entry Name:STIP1_HUMAN
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