Human STAMBPL1 Recombinant Protein (RPPB4839)
- SKU:
- RPPB4839
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- STAMBPL1
- Synonyms:
- ALMalpha
- AMSH-FP
- AMSH-LP
- bA399O192
- Source:
- Escherichia Coli
- Uniprot:
- Q96FJ0
Description
| Product Name: | Human STAMBPL1 Recombinant Protein |
| Product Code: | RPPB4839 |
| Size: | 10µg |
| Species: | Human |
| Target: | STAMBPL1 |
| Synonyms: | ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2, AMSH-like protease, STAM Binding Protein Like 1, STAMBPL1, AMSHLP, KIAA1373. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The STAMBPL1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSQ SHMDQPFTVN SLKKLAAMPD HTDVSLSPEE RVRALSKLGC NITISEDITP RRYFRSGVEM ERMASVYLEE GNLENAFVLY NKFITLFVEK LPNHRDYQQC AVPEKQDIMK KLKEIAFPRT DELKNDLLKK YNVEYQEYLQ SKNKYKAEIL KKLEHQRLIE AERKRIAQMR QQQLESEQFL FFEDQLKKQE LARGQMRSQQ TSGLSEQIDG SALSCFSTHQ NNSLLNVFAD QPNKSDATNY ASHSPPVNRA LTPAATLSAV QNLVVEGLRC VVLPEDLCHK FLQLAESNTV RGIETCGILC GKLTHNEFTI THVIVPKQSA GPDYCDMENV EELFNVQDQH DLLTLGWIHT HPTQTAFLSS VDLHTHCSYQ LMLPEAIAIV CSPKHKDTGI FRLTNAGMLE VSACKKKGFH PHTKEPRLFS ICKHVLVKDI KIIVLDLR |
STAM Binding Protein Like 1 (STAMBPL1) is a zinc metalloprotease which specifically cleaves 'Lys-63'-linked polyubiquitin chains, however, it doesn’t cleave 'Lys-48'-linked polyubiquitin chains. STAMBPL1 binds 2 zinc ions per subunit. The JAMM motif is vital for the protease activity. STAMBPL1 is a member of the peptidase M67C family. STAMBPL1 contains 1 MPN (JAB/Mov34) domain.
STAMBPL1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 458 amino acids (1-436) and having a molecular mass of 52 kDa. STAMBPL1 is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | STAMBPL1: Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Belongs to the peptidase M67C family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; EC 3.1.2.15; Protease; EC 3.4.19.- Chromosomal Location of Human Ortholog: 10q23.31 Cellular Component: membrane Molecular Function:protein binding; metallopeptidase activity; metal ion binding Biological Process: proteolysis |
| UniProt Code: | Q96FJ0 |
| NCBI GenInfo Identifier: | 33147080 |
| NCBI Gene ID: | 57559 |
| NCBI Accession: | NP_065850.1 |
| UniProt Secondary Accession: | Q96FJ0,Q5T9N4, Q5T9N9, Q7Z420, Q9P2H4, B3KPA7, |
| UniProt Related Accession: | Q96FJ0 |
| Molecular Weight: | 52,199 Da |
| NCBI Full Name: | AMSH-like protease |
| NCBI Synonym Full Names: | STAM binding protein-like 1 |
| NCBI Official Symbol: | STAMBPL1 |
| NCBI Official Synonym Symbols: | AMSH-FP; AMSH-LP; ALMalpha; bA399O19.2 |
| NCBI Protein Information: | AMSH-like protease; associated molecule with the SH3 domain of STAM (AMSH) like protein; associated molecule with the SH3 domain of STAM (AMSH) - Family Protein |
| UniProt Protein Name: | AMSH-like protease |
| UniProt Synonym Protein Names: | STAM-binding protein-like 1 |
| Protein Family: | AMSH-like protease |
| UniProt Gene Name: | STAMBPL1 |
| UniProt Entry Name: | STALP_HUMAN |
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