Human ST6GAL1 Recombinant Protein (RPPB2288)
- SKU:
- RPPB2288
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- ST6GAL1
- Synonyms:
- ST6 Beta-Galactoside Alpha-2
- 6-Sialyltransferase 1
- ST6Beta-Galactosamide Alpha-2
- 6-Sialyltranferase 1
- Source:
- Sf9 Insect cells
- Uniprot:
- P15907
Description
| Product Name: | Human ST6GAL1 Recombinant Protein |
| Product Code: | RPPB2288 |
| Size: | 10µg |
| Species: | Human |
| Target: | ST6GAL1 |
| Synonyms: | ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1, ST6Beta-Galactosamide Alpha-2,6-Sialyltranferase 1, ST6Gal I,CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2,6-Sialyltransferase 1,B-CellAntigen CD75, Alpha 2,6-ST 1, EC 2.4.99.1, ST6GalI, SIAT1,CMP-N-Acetylneuraminate Beta-Galactosamide Alpha-2,6-Sialyltransferase,Sialyltransferase 1 (Beta-Galactoside Alpha-2,6-Sialyltransferase) , ST6N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1, Sialyltransferase 1,ST6N. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ST6GAL1 protein solution (0.5mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPKEKKKGS YYDSFKLQTK EFQVLKSLGK LAMGSDSQSV SSSSTQDPHRGRQTLGSLRG LAKAKPEASF QVWNKDSSSK NLIPRLQKIW KNYLSMNKYK VSYKGPGPGI KFSAEALRCHLRDHVNVSMV EVTDFPFNTS EWEGYLPKES IRTKAGPWGR CAVVSSAGSL KSSQLGREID DHDAVLRFNGAPTANFQQDV GTKTTIRLMN SQLVTTEKRF LKDSLYNEGI LIVWDPSVYH SDIPKWYQNP DYNFFNNYKTYRKLHPNQPF YILKPQMPWE LWDILQEISP EEIQPNPPSS GMLGIIIMMT LCDQVDIYEF LPSKRKTDVCYYYQKFFDSA CTMGAYHPLL YEKNLVKHLN QGTDEDIYLL GKATLPGFRT IHCHHHHHH |
ST6GAL1 also known as ST6 Beta-Galactosamide Alpha-2,6-Sialyltranferase 1, is part of the glycosyltransferase family 29. ST6GAL1 is a type II membrane protein which catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. Furthermore, ST6GAL1 is normally found in the Golgi however it can be proteolytically processed to a soluble form, ST6GAL1 is also involved in the generation of the cell-surface carbohydrate determinants as well differentiation antigens HB-6, CD75, and CD76.
ST6GAL1 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 389 amino acids (27-406 a.a.) andhaving a molecular mass of 44.6kDa (Migrates at 40-57kDa on SDS-PAGE underreducing conditions).ST6GAL1 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SIAT1: a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. Is normally found in the trans cisternae of the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found. |
| UniProt Protein Details: | Protein type:EC 2.4.99.1; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Transferase Chromosomal Location of Human Ortholog: 3q27.3 Cellular Component: Golgi membrane Molecular Function:beta-galactoside alpha-2,6-sialyltransferase activity; protein binding; sialyltransferase activity Biological Process: humoral immune response; N-acetylneuraminate metabolic process; O-glycan processing; oligosaccharide metabolic process; protein amino acid N-linked glycosylation via asparagine |
| NCBI Summary: | This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009] |
| UniProt Code: | P15907 |
| NCBI GenInfo Identifier: | 115445 |
| NCBI Gene ID: | 6480 |
| NCBI Accession: | P15907.1 |
| UniProt Secondary Accession: | P15907,A8KA14, B2R513, D3DNV3, |
| UniProt Related Accession: | P15907 |
| Molecular Weight: | 47kDa |
| NCBI Full Name: | Beta-galactoside alpha-2,6-sialyltransferase 1 |
| NCBI Synonym Full Names: | ST6 beta-galactoside alpha-2,6-sialyltransferase 1 |
| NCBI Official Symbol: | ST6GAL1 |
| NCBI Official Synonym Symbols: | ST6N; SIAT1; ST6GalI |
| NCBI Protein Information: | beta-galactoside alpha-2,6-sialyltransferase 1 |
| UniProt Protein Name: | Beta-galactoside alpha-2,6-sialyltransferase 1 |
| UniProt Synonym Protein Names: | B-cell antigen CD75; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1 |
| Protein Family: | Beta-galactoside alpha-2,6-sialyltransferase |
| UniProt Gene Name: | ST6GAL1 |
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