Human SSX2 Recombinant Protein (RPPB4836)
- SKU:
- RPPB4836
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- SSX2
- Synonyms:
- Cancer/testis antigen family 5
- member 2b
- CT52b
- Protein SSX2
- Source:
- Escherichia Coli
- Uniprot:
- Q16385
Description
| Product Name: | Human SSX2 Recombinant Protein |
| Product Code: | RPPB4836 |
| Size: | 10µg |
| Species: | Human |
| Target: | SSX2 |
| Synonyms: | Cancer/testis antigen family 5, member 2b, CT5.2b, Protein SSX2, Cancer/testis antigen 5.2, Synovial sarcoma, X breakpoint 2, CT5.2, Tumor antigen HOM-MEL-40, SSX2, SSX2A, SSX2B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SSX2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH RSMNGDDAFA RRPTVGAQIP EKIQKAFDDI AKYFSKEEWE KMKASEKIFY VYMKRKYEAM TKLGFKATLP PFMCNKRAED FQGNDLDNDP NRGNQVERPQ MTFGRLQGIS PKIMPKKPAE EGNDSEEVPE ASGPQNDGKE LCPPGKPTTS EKIHERSGPK RGEHAWTHRL RERKQLVIYE EISDPEEDDE |
Synovial Sarcoma, X Breakpoint 2 (SSX2) is a part of the family of highly homologous synovial sarcoma X breakpoint proteins which play a role as transcriptional repressors. Homologous synovial sarcoma X breakpoint proteins are also able to bring out spontaneous humoral and cellular immune responses in cancer patients, and are effective targets in cancer vaccine-based immunotherapy.
SSX2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-188a.a) and having a molecular mass of 24.0kDa. SSX2 is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SSX2B: Could act as a modulator of transcription. A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). Belongs to the SSX family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: Xp11.22 Cellular Component: nucleus Molecular Function:protein binding; nucleic acid binding Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent |
| NCBI Summary: | The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 6757, located about 45 kb upstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q16385 |
| NCBI GenInfo Identifier: | 3915028 |
| NCBI Gene ID: | 6757 |
| NCBI Accession: | Q16385.2 |
| UniProt Secondary Accession: | Q16385,Q16404, Q5JS26, Q96IP7, Q9BU88, |
| UniProt Related Accession: | Q16385 |
| Molecular Weight: | 21kDa |
| NCBI Full Name: | Protein SSX2 |
| NCBI Synonym Full Names: | synovial sarcoma, X breakpoint 2B |
| NCBI Official Symbol: | SSX2B |
| NCBI Official Synonym Symbols: | SSX; CT5.2; CT5.2b; HOM-MEL-40 |
| NCBI Protein Information: | protein SSX2; tumor antigen HOM-MEL-40; cancer/testis antigen 5.2; cancer/testis antigen family 5, member 2b |
| UniProt Protein Name: | Protein SSX2 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 5.2; CT5.2; Synovial sarcoma, X breakpoint 2; Tumor antigen HOM-MEL-40 |
| Protein Family: | Protein |
| UniProt Gene Name: | SSX2 |
| UniProt Entry Name: | SSX2_HUMAN |
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