Human SRP14 Recombinant Protein (RPPB4826)

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SKU:
RPPB4826
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SRP14
Synonyms:
Signal recognition particle 14 kDa protein
Synonyms:
SRP14
Synonyms:
18 kDa Alu RNA-binding protein
Synonyms:
ALURBP
Source:
Escherichia Coli
Uniprot:
P37108
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Description

Product Name:Human SRP14 Recombinant Protein
Product Code:RPPB4826
Size:20µg
Species:Human
Target:SRP14
Synonyms:Signal recognition particle 14 kDa protein, SRP14, 18 kDa Alu RNA-binding protein, ALURBP, MGC14326.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The SRP14 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMVLLES EQFLTELTRL FQKCRTSGSV YITLKKYDGR TKPIPKKGTV EGFEPADNKC LLRATDGKKK ISTVVSSKEV NKFQMAYSNL LRANMDGLKK RDKKNKTKKT KAAAAAAAAA PAAAATAATT AATTAATAAQ

SRP14 is a ribonucleoprotein complex which mediates the directing of proteins to the endoplasmic reticulum. The “Alu domain” of SRP is comprised of the heterodimer of the SRP9 and SRP14 proteins that are bound to the 5' and 3' terminal sequences of SRP RNA. SRP9/14 binding may be critical to the transcription, maturation, nucleolus localization and transport of SRP RNA.

SRP14 Human Recombinant fused with a 24 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 160 amino acids (1-136 a.a.) and having a molecular mass of 17.1kDa. The SRP14 is purified by proprietary chromatographic techniques.

UniProt Protein Function:SRP14: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. Belongs to the SRP14 family.
UniProt Protein Details:

Protein type:RNA-binding; Translation

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: intercellular bridge; cytoplasm; nucleolus; signal recognition particle, endoplasmic reticulum targeting; cytosol; nucleus

Molecular Function:protein binding; RNA binding; endoplasmic reticulum signal peptide binding; 7S RNA binding

Biological Process: response to drug; SRP-dependent cotranslational protein targeting to membrane; protein targeting to ER; cellular protein metabolic process; translation; gene expression; cotranslational protein targeting to membrane

UniProt Code:P37108
NCBI GenInfo Identifier:116242801
NCBI Gene ID:6727
NCBI Accession:P37108.2
UniProt Secondary Accession:P37108,Q6B0K5, Q96Q14, B5BUF5,
UniProt Related Accession:P37108
Molecular Weight:136
NCBI Full Name:Signal recognition particle 14 kDa protein
NCBI Synonym Full Names:signal recognition particle 14kDa (homologous Alu RNA binding protein)
NCBI Official Symbol:SRP14  
NCBI Official Synonym Symbols:ALURBP  
NCBI Protein Information:signal recognition particle 14 kDa protein; 18 kDa Alu RNA-binding protein
UniProt Protein Name:Signal recognition particle 14 kDa protein
UniProt Synonym Protein Names:18 kDa Alu RNA-binding protein
Protein Family:Signal recognition particle
UniProt Gene Name:SRP14  
UniProt Entry Name:SRP14_HUMAN
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