Human SP100 Recombinant Protein (RPPB4786)

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SKU:
RPPB4786
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SP100
Synonyms:
Nuclear dot-associated Sp100 protein
Synonyms:
SP100 nuclear antigen
Synonyms:
Speckled 100 kDa
Synonyms:
SP100-HMG nuclear autoantigen
Source:
Sf9 Insect cells
Uniprot:
P23497
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Description

Product Name:Human SP100 Recombinant Protein
Product Code:RPPB4786
Size:20µg
Species:Human
Target:SP100
Synonyms:Nuclear dot-associated Sp100 protein, SP100 nuclear antigen, Speckled 100 kDa, SP100-HMG nuclear autoantigen, FLJ00340, Lysp100b.
Source:Sf9 Insect cells
Formulation:Sp100 is supplied in 16mM HEPES buffer pH-8.0, 400mM NaCl, and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.

SP100 protein is Homodimer which takes part in the control of gene expression. SP100 interacts with members of the HP1 family of nonhistone chromosomal protein, such as CBX5 and CBX3 via the PxVxL motif and also interacts with Epstein-Barr virus EBNA-LP.The major isoform Sp100-A, has a calculated MW of 54 kDa, but exhibits aberrant electrophoretic mobilities, with an apparent MW OF 100 kDa.

Recombinant Sp100 antigen is a full-length cDNA coding having a molecular mass of 54,662 Dalton (pH 5.0).Shows a 79kDa band on SDS-PAGE. Sp100 protein is fused to a hexa-histidine purification tag.

UniProt Protein Function:Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.
NCBI Summary:This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
UniProt Code:P23497
NCBI GenInfo Identifier:13878931
NCBI Gene ID:6672
NCBI Accession:P23497.3
UniProt Secondary Accession:P23497,O75450, Q13343, Q8TE34, Q96F70, Q96T24, Q96T95 B4DDX5, B8ZZD8, E7EUA7, E9PH61, F8WFE2,
UniProt Related Accession:P23497
Molecular Weight:50,032 Da
NCBI Full Name:Nuclear autoantigen Sp-100
NCBI Synonym Full Names:SP100 nuclear antigen
NCBI Official Symbol:SP100  
NCBI Official Synonym Symbols:lysp100b  
NCBI Protein Information:nuclear autoantigen Sp-100
UniProt Protein Name:Nuclear autoantigen Sp-100
UniProt Synonym Protein Names:Nuclear dot-associated Sp100 protein; Speckled 100 kDa
Protein Family:Nuclear autoantigen
UniProt Gene Name:SP100  
UniProt Entry Name:SP100_HUMAN
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