Human SNX5 Recombinant Protein (RPPB4769)

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SKU:
RPPB4769
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SNX5
Synonyms:
Sorting nexin-5 isoform a
Synonyms:
Sorting nexin-5
Synonyms:
SNX5
Source:
Escherichia Coli
Uniprot:
Q9Y5X3
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Description

Product Name:Human SNX5 Recombinant Protein
Product Code:RPPB4769
Size:10µg
Species:Human
Target:SNX5
Synonyms:Sorting nexin-5 isoform a, Sorting nexin-5, SNX5.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:SNX5 protein solution (0.25mg/ml) in phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAAVPEL LQQQEEDRSK LRSVSVDLNV DPSLQIDIPD ALSERDKVKFTVHTKTTLPT FQSPEFSVTR QHEDFVWLHD TLIETTDYAG LIIPPAPTKP DFDGPREKMQ KLGEGEGSMTKEEFAKMKQE LEAEYLAVFK KTVSSHEVFL QRLSSHPVLS KDRNFHVFLE YDQDLSVRRK NTKEMFGGFFKSVVKSADEV LFTGVKEVDD FFEQEKNFLI NYYNRIKDSC VKADKMTRSH KNVADDYIHT AACLHSLALEEPTVIKKYLL KVAELFEKLR KVEGRVSSDE DLKLTELLRY YMLNIEAAKD LLYRRTKALI DYENSNKALDKARLKSKDVK LAEAHQQECC QKFEQLSESA KEELINFKRK RVAAFRKNLI EMSELEIKHA RNNVSLLQSCIDLFKNN

Sorting nexin-5 (SNX5) belongs to the sorting nexin family, whose members contains a phox (PX) domain, (which is a phosphoinositide binding domain) and are involved in intracellular trafficking. SNX5 protein is a component of the mammalian retromer complex, which facilitates cargo recovery from endosomes to the trans-Golgi network. SNX5 binds to the Fanconi anemia, complementation group A protein.

SNX5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 427 amino acids (1-404 a.a) and having a molecular mass of 49.2kDa.SNX5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SNX5: May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation. Belongs to the sorting nexin family.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 20p11

Cellular Component: ruffle; extrinsic to internal side of plasma membrane; cytoplasmic vesicle membrane; early endosome membrane; retromer complex; phagocytic cup

Molecular Function:protein binding; phosphoinositide binding

Biological Process: pinocytosis; intracellular protein transport; vesicle organization and biogenesis; retrograde transport, endosome to Golgi

NCBI Summary:This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
UniProt Code:Q9Y5X3
NCBI GenInfo Identifier:10720289
NCBI Gene ID:27131
NCBI Accession:Q9Y5X3.1
UniProt Secondary Accession:Q9Y5X3,Q52LC4, Q7KZN0, Q9BWP0, B7ZKN3, D3DW26,
UniProt Related Accession:Q9Y5X3
Molecular Weight:404
NCBI Full Name:Sorting nexin-5
NCBI Synonym Full Names:sorting nexin 5
NCBI Official Symbol:SNX5  
NCBI Protein Information:sorting nexin-5
UniProt Protein Name:Sorting nexin-5
Protein Family:Sorting nexin
UniProt Gene Name:SNX5  
UniProt Entry Name:SNX5_HUMAN
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