Human SNRPE Recombinant Protein (RPPB4760)
- SKU:
- RPPB4760
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- SNRPE
- Synonyms:
- Small nuclear ribonucleoprotein E
- snRNP-E
- Sm protein E
- Sm-E
- Source:
- Escherichia Coli
- Uniprot:
- P62304
Description
| Product Name: | Human SNRPE Recombinant Protein |
| Product Code: | RPPB4760 |
| Size: | 5µg |
| Species: | Human |
| Target: | SNRPE |
| Synonyms: | Small nuclear ribonucleoprotein E, snRNP-E, Sm protein E, Sm-E, SmE, SNRPE, B-raf. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SNRPE solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT, 1mM EDTA and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN |
SNRPE facilitates the cytoplasmic construction of the UsnRNPs by binding to a conserved Sm site on UsnRNA and forming a stable snRNP core complex. While a core protein to UsnRNP, the SNRPE connects with the entire U family of snRNAs including U1–U6. In addition, SNRPE interacts with DDX20 and Small nuclear ribonucleoprotein polypeptide F.
SNRPE Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 112 amino acids (1-92 a.a.) and having a molecular mass of 12.9kDa. The SNRPE is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | snRNP E: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. |
| UniProt Protein Details: | Protein type:Spliceosome; RNA splicing Chromosomal Location of Human Ortholog: 1q32 Cellular Component: nucleoplasm; small nuclear ribonucleoprotein complex; spliceosome; U4/U6 x U5 tri-snRNP complex; snRNP U5; snRNP U2; snRNP U1; nucleus; cytosol; U12-dependent spliceosome Molecular Function:protein binding; RNA binding Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis; RNA splicing; histone mRNA metabolic process; spliceosome assembly; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription; hair cycle Disease: Hypotrichosis 11 |
| UniProt Code: | P62304 |
| NCBI GenInfo Identifier: | 61237380 |
| NCBI Gene ID: | 6635 |
| NCBI Accession: | P62304.1 |
| UniProt Secondary Accession: | P62304,P08578, Q15498, Q5BKT2, B2R5B9, |
| UniProt Related Accession: | P62304 |
| Molecular Weight: | 92 |
| NCBI Full Name: | Small nuclear ribonucleoprotein E |
| NCBI Synonym Full Names: | small nuclear ribonucleoprotein polypeptide E |
| NCBI Official Symbol: | SNRPE |
| NCBI Official Synonym Symbols: | SME; Sm-E; B-raf; HYPT11 |
| NCBI Protein Information: | small nuclear ribonucleoprotein E; snRNP-E; sm protein E |
| UniProt Protein Name: | Small nuclear ribonucleoprotein E |
| UniProt Synonym Protein Names: | Sm protein E; Sm-E; SmE |
| Protein Family: | Small nuclear ribonucleoprotein |
| UniProt Gene Name: | SNRPE |
| UniProt Entry Name: | RUXE_HUMAN |
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