Human SNRPB2 Recombinant Protein (RPPB4751)

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SKU:
RPPB4751
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SNRPB2
Synonyms:
Small nuclear ribonucleoprotein polypeptide B2
Synonyms:
Msl1
Synonyms:
U2 snRNP B''
Synonyms:
U2 small nuclear ribonucleoprotein B''
Source:
Escherichia Coli
Uniprot:
P08579
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Description

Product Name:Human SNRPB2 Recombinant Protein
Product Code:RPPB4751
Size:10µg
Species:Human
Target:SNRPB2
Synonyms:Small nuclear ribonucleoprotein polypeptide B2, Msl1, U2 snRNP B'', U2 small nuclear ribonucleoprotein B'', MGC24807, MGC45309.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The SNRPB2 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 40% glycerol and 0.1M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MDIRPNHTIY INNMNDKIKK EELKRSLYAL FSQFGHVVDI VALKTMKMRG QAFVIFKELG SSTNALRQLQ GFPFYGKPMR IQYAKTDSDI ISKMRGTFAD KEKKKEKKKA KTVEQTATTT NKKPGQGTPN SANTQGNSTP NPQVPDYPPN YILFLNNLPE  ETNEMMLSML FNQFPGFKEV RLVPGRHDIA FVEFENDGQA GAARDALQGF KITPSHAMKI TYAKK

SNRPB2 is a member of the RRM U1 A/B family. SNRPB2 links with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A. SNRPB2 has a part in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus often identify epitopes on the encoded protein. A pair of transcript variants encoding the same protein were identified for this gene.

SNRPB2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 245 amino acids (1-225a.a.) and having a molecular mass of 27.6kDa. The SNRPB2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:snRNP B2: a small nuclear ribonucleoprotein. Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the A' protein.
UniProt Protein Details:

Protein type:RNA processing; RNA splicing; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 20p12.1

Cellular Component: nucleolus; nucleoplasm; snRNP U2; spliceosome

Molecular Function:protein binding

Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of defense response to virus by host

NCBI Summary:The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P08579
NCBI GenInfo Identifier:134095
NCBI Gene ID:6629
NCBI Accession:P08579.1
UniProt Secondary Accession:P08579,Q9UJD4, B2R7J3, D3DW21,
UniProt Related Accession:P08579
Molecular Weight:25,486 Da
NCBI Full Name:U2 small nuclear ribonucleoprotein B''
NCBI Synonym Full Names:small nuclear ribonucleoprotein polypeptide B2
NCBI Official Symbol:SNRPB2  
NCBI Official Synonym Symbols:Msl1; U2B''  
NCBI Protein Information:U2 small nuclear ribonucleoprotein B''
UniProt Protein Name:U2 small nuclear ribonucleoprotein B''
UniProt Gene Name:SNRPB2  
UniProt Entry Name:RU2B_HUMAN
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