Human SNPH Recombinant Protein (RPPB4745)

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SKU:
RPPB4745
Product type:
Recombinant Protein
Size:
50ug
Species:
Human
Target:
SNPH
Synonyms:
KIAA0374
Synonyms:
MGC46096
Synonyms:
bA314N135
Synonyms:
SNPH
Source:
Escherichia Coli
Uniprot:
O15079
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Description

Product Name:Human SNPH Recombinant Protein
Product Code:RPPB4745
Size:50µg
Species:Human
Target:SNPH
Synonyms:KIAA0374, MGC46096, bA314N13.5, SNPH, Syntaphilin.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The Syntaphilin protein solution contains 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAMSLPGSRR TSAGSRRRTS PPVSVRDAYG TSSLSSSSNS GSYKGSDSSP TPRRSMKYTL CSDNHGIKPPTPEQYLTPLQ QKEVCIRHLK ARLKDTQDRL QDRDTEIDDL KTQLSRMQED WIEEECHRVE AQLALKEARK EIKQLKQVID TVKNNLIDKDKGLQKYFVDI NIQNKKLETL LHSMEVAQNG MAKEDGTGES AGGSPARSLT RSSTYTKLSD PAVCGDRQPG DPSSGSAEDG ADSGFAAADDTLSRTDALEA SSLLSSGVDC GTEETSLHSS FGLGPRFPAS NTYEKLLCGM EAGVQASCMQ ERAIQTDFVQ YQPDLDTILE KVTQAQVCGTDPESGDRCPE LDAHPSGPRD PNSAVVVTVG DELEAPEPIT RGPTPQRPGA NPNPGQSVSV VCPMEEEEEA AVAEKEPKSY WSRH

Syntaxin-1, synaptobrevin, and SNAP25 cooperate to form the SNARE complex, which is needed for synaptic vesicle docking and fusion SNPH is a neuron-specific protein originally characterized as a binding partner of syntaxin-1. SNPH participates with SNAP25 for the binding to Syntaxin-1 and prevents the construction of the SNARE core complex, thus manageling free syntaxin-1 availability for the assembly of the SNARE complex and potentially regulating synaptic vesicle exocytosis. Expression Syntaphilin appears to be brain-specific. SNPH is an inhibitor of both SNARE-based fusion and dynamin-mediated endocytosis.

SNPH Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 444 amino acids (1-424) and having a molecular mass of 48.2 kDa.The SNPH is fused to 20 amino acid His-Tag at N-terminus and purified by standard chromatography techniques.

UniProt Protein Function:syntaphilin: Inhibits SNARE complex formation by absorbing free syntaxin-1. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: presynaptic membrane; neuron projection; cell soma; cytoplasmic microtubule; mitochondrial membrane; cytoplasm; integral to membrane; cell junction

Molecular Function:syntaxin-1 binding

Biological Process: neuron differentiation; neurotransmitter secretion; brain development; synaptic vesicle docking during exocytosis

NCBI Summary:Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. [provided by RefSeq, Jul 2008]
UniProt Code:O15079
NCBI GenInfo Identifier:21362912
NCBI Gene ID:9751
NCBI Accession:O15079.1
UniProt Secondary Accession:O15079,Q8IYI3,
UniProt Related Accession:O15079
Molecular Weight:57,990 Da
NCBI Full Name:Syntaphilin
NCBI Synonym Full Names:syntaphilin
NCBI Official Symbol:SNPH  
NCBI Official Synonym Symbols:bA314N13.5  
NCBI Protein Information:syntaphilin
UniProt Protein Name:Syntaphilin
Protein Family:Syntaphilin
UniProt Gene Name:SNPH  
UniProt Entry Name:SNPH_HUMAN
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