Human SNAP23 Recombinant Protein (RPPB4722)
- SKU:
- RPPB4722
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- SNAP23
- Synonyms:
- SNAP23A
- SNAP23B
- HsT17016
- Synaptosomal-associated protein 23
- Source:
- Escherichia Coli
- Uniprot:
- O00161
Description
| Product Name: | Human SNAP23 Recombinant Protein |
| Product Code: | RPPB4722 |
| Size: | 25µg |
| Species: | Human |
| Target: | SNAP23 |
| Synonyms: | SNAP23A, SNAP23B, HsT17016, Synaptosomal-associated protein 23, Vesicle-membrane fusion protein SNAP-23, SNAP23. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The protein solution contains 20mM Tris-HCl pH-8. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MDNLSSEEIQ QRAHQITDES LESTRRILGL AIESQDAGIK TITMLDEQKE QLNRIEEGLD QINKDMRETE KTLTELNKCC GLCVCPCNRT KNFESGKAYK TTWGDGGENS PCNVVSKQPG PVTNGQLQQP TTGAASGGYI KRITNDARED EMEENLTQVG SILGNLKDMA LNIGNEIDAQ NPQIKRITDK ADTNRDRIDI ANARAKKLID S |
SNAP23 is a non-neuronal SNAP25 protein homologue and a target SNARE ubiquitously expressed on the plasma membrane and other intracellular membranes. SNAP23 is involved in exocytotic membrane fusion in most cells that do not express SNAP-25. SNAP23 is an essential component of the high affinity receptor for the general membrane fusion machinery and an crucial regulator of transport vesicle docking and fusion. SNAP23 is phosphorylated in platelets through cell activation during a protein kinase C-related mechanism at two or more sites. SNAP23, the ubiqitously expressed homologue of SNAP25, interacts directly with ubiquitous kinesin heavy chain (uKHC). SNAP-23 is expressed in human eosinophils and is a candidates for association with VAMP-2 during docking, which is followed by exocytosis.
SNAP23 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids and having a molecular mass of 23.3 kDa.
| UniProt Protein Function: | SNAP23: a member of the SNAP-25 family of SNARE proteins. Structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 15q14 Cellular Component: nucleoplasm; SNARE complex; azurophil granule; specific granule; neuron projection; mast cell granule; focal adhesion; cytoplasm; plasma membrane; synapse Molecular Function:SNAP receptor activity; protein binding; syntaxin binding Biological Process: synaptic vesicle fusion to presynaptic membrane; protein transport; histamine secretion by mast cell; vesicle targeting; post-Golgi vesicle-mediated transport; synaptic vesicle priming |
| NCBI Summary: | Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00161 |
| NCBI GenInfo Identifier: | 6685971 |
| NCBI Gene ID: | 8773 |
| NCBI Accession: | O00161.1 |
| UniProt Secondary Accession: | O00161,O00162, Q13602, Q6IAE3, |
| UniProt Related Accession: | O00161 |
| Molecular Weight: | 17,789 Da |
| NCBI Full Name: | Synaptosomal-associated protein 23 |
| NCBI Synonym Full Names: | synaptosomal-associated protein, 23kDa |
| NCBI Official Symbol: | SNAP23 |
| NCBI Official Synonym Symbols: | SNAP-23; SNAP23A; SNAP23B; HsT17016 |
| NCBI Protein Information: | synaptosomal-associated protein 23; synaptosomal-associated protein, 23kD; vesicle-membrane fusion protein SNAP-23 |
| UniProt Protein Name: | Synaptosomal-associated protein 23 |
| UniProt Synonym Protein Names: | Vesicle-membrane fusion protein SNAP-23 |
| Protein Family: | Synaptosomal-associated protein |
| UniProt Gene Name: | SNAP23 |
| UniProt Entry Name: | SNP23_HUMAN |
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