Human SIVA1 Recombinant Protein (RPPB4697)
- SKU:
- RPPB4697
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- SIVA1
- Synonyms:
- Apoptosis regulatory protein Siva isoform 1
- Apoptosis regulatory protein Siva
- CD27-binding protein
- CD27BP
- Source:
- Escherichia Coli
- Uniprot:
- O15304
Description
| Product Name: | Human SIVA1 Recombinant Protein |
| Product Code: | RPPB4697 |
| Size: | 20µg |
| Species: | Human |
| Target: | SIVA1 |
| Synonyms: | Apoptosis regulatory protein Siva isoform 1, Apoptosis regulatory protein Siva, CD27-binding protein, CD27BP, SIVA, SIVA1, Siva-1, Siva-2 |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The SIVA1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPKRSCP FADVAPLQLK VRVSQRELSR GVCAERYSQE VFEKTKRLLF LGAQAYLDHV WDEGCAVVHL PESPKPGPTG APRAARGQML IGPDGRLIRS LGQASEADPS GVASIACSSC VRAVDGKAVC GQCERALCGQ CVRTCWGCGS VACTLCGLVD CSDMYEKVLC TSCAMFET |
SIVA1, also referred to asApoptosis regulatory protein Siva isoform 1, is a death domain-containing proapoptotic protein. It is known as glucocorticoid-induced TNFR family-related gene, and also as an intracellular ligand of CD27, which are both members of the TNFR family expressed on lymphoid cells. There isn’t much known about the signalling pathway underlying the Siva-induced apoptosis.SIVA1 expression is modulated in multiple pathological processes.
SIVA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids (1-175 a.a.) and having a molecular mass of 21.1 kDa. SIVA1 is fused to a 23 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Siva: a proapoptotic protein. Associates with CD27, a member of the tumor necrosis factor receptor family. Two alternatively spliced isoforms have been described. Isoform 1 but not isoform 2 may induce TNFRSF7/CD27 mediated apoptosis. Isoform 1 inhibits Bcl-xL anti-apoptotic activity. |
| UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 14q32.33 Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus Molecular Function:viral receptor activity; protein binding; zinc ion binding; metal ion binding; CD27 receptor binding Biological Process: entry of virus into host cell; inhibition of NF-kappaB transcription factor; activated T cell apoptosis |
| NCBI Summary: | This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15304 |
| NCBI GenInfo Identifier: | 31077008 |
| NCBI Gene ID: | 10572 |
| NCBI Accession: | O15304.2 |
| UniProt Secondary Accession: | O15304,Q96P98, Q9UPD6, |
| UniProt Related Accession: | O15304 |
| Molecular Weight: | 175 |
| NCBI Full Name: | Apoptosis regulatory protein Siva |
| NCBI Synonym Full Names: | SIVA1, apoptosis-inducing factor |
| NCBI Official Symbol: | SIVA1 |
| NCBI Official Synonym Symbols: | SIVA; CD27BP; Siva-1; Siva-2 |
| NCBI Protein Information: | apoptosis regulatory protein Siva; CD27-binding (Siva) protein |
| UniProt Protein Name: | Apoptosis regulatory protein Siva |
| UniProt Synonym Protein Names: | CD27-binding protein; CD27BP |
| Protein Family: | Apoptosis regulatory protein |
| UniProt Gene Name: | SIVA1 |
| UniProt Entry Name: | SIVA_HUMAN |
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