Human SIVA1 Recombinant Protein (RPPB4697)

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SKU:
RPPB4697
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SIVA1
Synonyms:
Apoptosis regulatory protein Siva isoform 1
Synonyms:
Apoptosis regulatory protein Siva
Synonyms:
CD27-binding protein
Synonyms:
CD27BP
Source:
Escherichia Coli
Uniprot:
O15304
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Description

Product Name:Human SIVA1 Recombinant Protein
Product Code:RPPB4697
Size:20µg
Species:Human
Target:SIVA1
Synonyms:Apoptosis regulatory protein Siva isoform 1, Apoptosis regulatory protein Siva, CD27-binding protein, CD27BP, SIVA, SIVA1, Siva-1, Siva-2
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The SIVA1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPKRSCP FADVAPLQLK VRVSQRELSR GVCAERYSQE VFEKTKRLLF LGAQAYLDHV WDEGCAVVHL PESPKPGPTG APRAARGQML IGPDGRLIRS LGQASEADPS GVASIACSSC VRAVDGKAVC GQCERALCGQ CVRTCWGCGS VACTLCGLVD CSDMYEKVLC TSCAMFET

SIVA1, also referred to asApoptosis regulatory protein Siva isoform 1, is a death domain-containing proapoptotic protein. It is known as glucocorticoid-induced TNFR family-related gene, and also as an intracellular ligand of CD27, which are both members of the TNFR family expressed on lymphoid cells. There isn’t much known about the signalling pathway underlying the Siva-induced apoptosis.SIVA1 expression is modulated in multiple pathological processes.

SIVA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids (1-175 a.a.) and having a molecular mass of 21.1 kDa. SIVA1 is fused to a 23 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Siva: a proapoptotic protein. Associates with CD27, a member of the tumor necrosis factor receptor family. Two alternatively spliced isoforms have been described. Isoform 1 but not isoform 2 may induce TNFRSF7/CD27 mediated apoptosis. Isoform 1 inhibits Bcl-xL anti-apoptotic activity.
UniProt Protein Details:

Protein type:Apoptosis

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus

Molecular Function:viral receptor activity; protein binding; zinc ion binding; metal ion binding; CD27 receptor binding

Biological Process: entry of virus into host cell; inhibition of NF-kappaB transcription factor; activated T cell apoptosis

NCBI Summary:This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]
UniProt Code:O15304
NCBI GenInfo Identifier:31077008
NCBI Gene ID:10572
NCBI Accession:O15304.2
UniProt Secondary Accession:O15304,Q96P98, Q9UPD6,
UniProt Related Accession:O15304
Molecular Weight:175
NCBI Full Name:Apoptosis regulatory protein Siva
NCBI Synonym Full Names:SIVA1, apoptosis-inducing factor
NCBI Official Symbol:SIVA1  
NCBI Official Synonym Symbols:SIVA; CD27BP; Siva-1; Siva-2  
NCBI Protein Information:apoptosis regulatory protein Siva; CD27-binding (Siva) protein
UniProt Protein Name:Apoptosis regulatory protein Siva
UniProt Synonym Protein Names:CD27-binding protein; CD27BP
Protein Family:Apoptosis regulatory protein
UniProt Gene Name:SIVA1  
UniProt Entry Name:SIVA_HUMAN
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