Human SIT1 Recombinant Protein (RPPB4696)

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주문
SKU:
RPPB4696
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
SIT1
Synonyms:
Signaling threshold-regulating transmembrane adapter 1
Synonyms:
SHP2-interacting transmembrane adapter protein
Synonyms:
Suppression-inducing transmembrane adapter 1
Synonyms:
gp30/40
Source:
Escherichia Coli
Uniprot:
Q9Y3P8
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Description

Product Name:Human SIT1 Recombinant Protein
Product Code:RPPB4696
Size:5µg
Species:Human
Target:SIT1
Synonyms:Signaling threshold-regulating transmembrane adapter 1, SHP2-interacting transmembrane adapter protein, Suppression-inducing transmembrane adapter 1, gp30/40, SIT1, SIT, RP11-331F9.5, MGC125908, MGC125909, MGC125910.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SIT1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0) and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MHLSQWTRGR SRSHPGQGRS GESVEEVPLY GNLHYLQTGR LSQDPEPDQQ DPTLGGPARA AEEVMCYTSL QLRPPQGRIP GPGTPVKYSE VVLDSEPKSQ ASGPEPELYA SVCAQTRRAR ASFPDQAYAN SQPAAS
UniProt Code:Q9Y3P8

Signaling threshold-regulating transmembrane adapter 1 (SIT1) negatively regulates T-cell antigen receptor (TCR)-mediated signaling in T-cells. SIT1 is involved in positive selection of T-cells. SIT1 is specifically expressed in T- and B-cells. SIT1 is also present in plasma cells but not in germinal center B-cells (at protein level). SIT1 is expressed in T- and B-cell lymphoma.

SIT1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 156 amino acids (62-196 a.a.) and having a molecular mass of 16.9kDa (Molecular weight on SDS-PAGE will appear higher).SIT1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

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