Human SIRT3 Recombinant Protein (RPPB4693)

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주문
SKU:
RPPB4693
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SIRT3
Synonyms:
Sirtuin 3
Synonyms:
SIR2-like protein 3
Synonyms:
Sir2-like 3
Synonyms:
NAD-dependent deacetylase sirtuin-3
Source:
Escherichia Coli
Uniprot:
Q9NTG7
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Description

Product Name:Human SIRT3 Recombinant Protein
Product Code:RPPB4693
Size:10µg
Species:Human
Target:SIRT3
Synonyms:Sirtuin 3, SIR2-like protein 3, Sir2-like 3, NAD-dependent deacetylase sirtuin-3, mitochondrial.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The SIRT3 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 1mM DTT, 0.1M NaCl, 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSDKGKLSLQ DVAELIRARA CQRVVVMVGA GISTPSGIPD FRSPGSGLYS NLQQYDLPYP EAIFELPFFF HNPKPFFTLA KELYPGNYKP NVTHYFLRLL HDKGLLLRLY TQNIDGLERV SGIPASKLVE AHGTFASATC TVCQRPFPGE DIRADVMADR VPRCPVCTGV VKPDIVFFGE PLPQRFLLHV VDFPMADLLL ILGTSLEVEP FASLTEAVRS SVPRLLINRD LVGPLAWHPR SRDVAQLGDV VHGVESLVEL LGWTEEMRDL VQRETGKLDG PDK

SIRT3 is a member of a family of proteins called Sirtuin. Proteins of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The roles of human Sirtuins are numerous and are important in aging prosseses, stress resistance and metabolic regulation. SIRT3 shows NAD+-dependent deacetylase activity in the mitochondria. Over-expression of SIRT3 causes increased levels of the mitochondrial uncoupling protein 1. Also, in certain breast cancers the levels of SIRT3 protein are found to be extremely high.

SIRT3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 303 amino acids (118-399a.a.) and having a molecular mass of 33.5kDa.SIRT3 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Code:Q9NTG7
NCBI GenInfo Identifier:38258651
NCBI Gene ID:23410
NCBI Accession:Q9NTG7.2
UniProt Secondary Accession:Q9NTG7,Q9Y6E8, B7Z5U6,
UniProt Related Accession:Q9NTG7
Molecular Weight:399
NCBI Full Name:NAD-dependent protein deacetylase sirtuin-3, mitochondrial
NCBI Synonym Full Names:sirtuin 3
NCBI Official Symbol:SIRT3  
NCBI Official Synonym Symbols:SIR2L3  
NCBI Protein Information:NAD-dependent protein deacetylase sirtuin-3, mitochondrial; sir2-like 3; sirtuin type 3; SIR2-like protein 3; regulatory protein SIR2 homolog 3; NAD-dependent deacetylase sirtuin-3, mitochondrial; silent mating type information regulation 2, S.cerevisiae, homolog 3; mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
UniProt Protein Name:NAD-dependent protein deacetylase sirtuin-3, mitochondrial
UniProt Synonym Protein Names:Regulatory protein SIR2 homolog 3; SIR2-like protein 3
Protein Family:NAD-dependent protein deacetylase sirtuin
UniProt Gene Name:SIRT3  
UniProt Entry Name:SIR3_HUMAN
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