Human SH3GL3 Recombinant Protein (RPPB4667)

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SKU:
RPPB4667
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SH3GL3
Synonyms:
SH3-Domain GRB2-Like 3
Synonyms:
SH3 Domain-Containing GRB2-Like Protein 3
Synonyms:
SH3 Domain Protein 2C
Synonyms:
Endophilin-3
Source:
Escherichia Coli
Uniprot:
Q99963
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Description

Product Name:Human SH3GL3 Recombinant Protein
Product Code:RPPB4667
Size:20µg
Species:Human
Target:SH3GL3
Synonyms:SH3-Domain GRB2-Like 3, SH3 Domain-Containing GRB2-Like Protein 3, SH3 Domain Protein 2C, Endophilin-3, EEN-B2, SH3D2C, CNSA3, Endophilin-A3, HsT19371, SH3P13, EEN-2B-L3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:SH3GL3 protein solution (1mg/ml) containing PBS (pH 7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSVAGLK KQFHKASQLF SEKISGAEGT KLDDEFLDME RKIDVTNKVV AEILSKTTEY LQPNPAYRAK LGMLNTVSKI RGQVKTTGYP QTEGLLGDCM LKYGKELGED STFGNALIEV GESMKLMAEV KDSLDINVKQ TFIDPLQLLQ DKDLKEIGHH LKKLEGRRLD YDYKKKRVGK IPDEEVRQAV EKFEESKELA ERSMFNFLEN DVEQVSQLAV FIEAALDYHR QSTEILQELQ SKLQMRISAA SSVPRREYKP RPVKRSSSEL NGVSTTSVVK TTGSNIPMDQ PCCRGLYDFE PENQGELGFK EGDIITLTNQ IDENWYEGMI HGESGFFPIN YVEVIVPLPQ

SH3-DomainGRB2-Like 3, also known as SH3GL3, is a part of the endophilin family. SH3GL3 contains1 BAR domain and 1 SH3 domain and takes part in endocytosis. SH3GL3 is aprotein coding gene which drafts proteins with high curvature tomembranes.

SH3GL3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 370 amino acids (1-347 a.a) and having a molecular mass of 41.7kDa. SH3GL3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SH3GL3: Implicated in endocytosis. May recruit other proteins to membranes with high curvature. Belongs to the endophilin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: early endosome membrane

Molecular Function:identical protein binding; protein binding; lipid binding

Biological Process: central nervous system development; endocytosis; signal transduction

UniProt Code:Q99963
NCBI GenInfo Identifier:12643798
NCBI Gene ID:6457
NCBI Accession:Q99963.1
UniProt Related Accession:Q99963
Molecular Weight:
NCBI Full Name:Endophilin-A3
NCBI Synonym Full Names:SH3 domain containing GRB2 like 3, endophilin A3
NCBI Official Symbol:SH3GL3  
NCBI Official Synonym Symbols:CNSA3; EEN-B2; SH3D2C; SH3P13; HsT19371  
NCBI Protein Information:endophilin-A3
UniProt Protein Name:Endophilin-A3
UniProt Synonym Protein Names:EEN-B2; Endophilin-3; SH3 domain protein 2C; SH3 domain-containing GRB2-like protein 3
UniProt Gene Name:SH3GL3  
UniProt Entry Name:SH3G3_HUMAN
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