Human SGTA Recombinant Protein (RPPB4666)
- SKU:
- RPPB4666
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- SGTA
- Synonyms:
- alphaSGT
- hSGT
- SGT
- Vpu-binding protein
- Source:
- Escherichia Coli
- Uniprot:
- O43765
Description
| Product Name: | Human SGTA Recombinant Protein |
| Product Code: | RPPB4666 |
| Size: | 25µg |
| Species: | Human |
| Target: | SGTA |
| Synonyms: | alphaSGT, hSGT, SGT, Vpu-binding protein, UBP, Small glutamine-rich tetratricopeptide repeat-containing protein alpha, Alpha-SGT, SGT1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | SGTA Human solution containing 20mM Trsi HCL pH-8, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MDNKKRLAYA IIQFLHDQLR HGGLSSDAQE SLEVAIQCLE TAFGVTVEDS DLALPQTLPE IFEAAATGKE MPQDLRSPAR TPPSEEDSAE AERLKTEGNE QMKVENFEAA VHFYGKAIEL NPANAVYFCN RAAAYSKLGN YAGAVQDCER AICIDPAYSK AYGRMGLALS SLNKHVEAVA YYKKALELDP DNETYKSNLK IAELKLREAP SPTGGVGSFD IAGLLNNPGF MSMASNLMNN PQIQQLMSGM ISGGNNPLGT PGTSPSQNDL ASLIQAGQQF AQQMQQQNPE LIEQLRSQIR SRTPSASNDD QQELEHHHHH H |
SGTA is a ubiquitously expressed protein that contains three TPR protein-protein interaction duplicates. SGTA takes part as a component of the androgen receptor (AR)-chaperone-cochaperone complex, functions as a cochaperone and participates in androgen signaling. SGTA binds directly to HSC70 and HSP70 and mediates their ATPase activity. SGTA gene encodes a protein that is able to interact with the chief nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate. In addition, SGTA interacts with Vpu and Gag from HIV-1, SARS-CoV accessory protein 7a, DNAJC5 and DNAJC5B. Since this transcript is expressed universally in several tissues, SGTA serves a housekeeping function. While being involved in apoptosis and androgen signaling, SGTA is a possible molecule for polycystic ovary syndrome, a disorder characterized by androgen excess, obesity and menstrual disturbances.
SGTA Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 321 amino acids (1-313 a.a.) and having a molecular mass of 35.1 kDa. SGTA protein is fused to a 8 amino acid His-Tag at C-terminus and purified by standard chromatography.
| UniProt Protein Function: | SGTA: Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. Homooligomerize. Interacts with NS1 from parvovirus H-1, with Vpu and Gag from HIV-1. Interacts with SARS- CoV accessory protein 7a. Interacts with DNAJC5 and DNAJC5B. Ubiquitous. Belongs to the SGT family. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 19p13 Cellular Component: cytoplasm Molecular Function:protein binding Biological Process: viral reproduction |
| NCBI Summary: | This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43765 |
| NCBI GenInfo Identifier: | 8134666 |
| NCBI Gene ID: | 6449 |
| NCBI Accession: | O43765.1 |
| UniProt Related Accession: | O43765 |
| Molecular Weight: | |
| NCBI Full Name: | Small glutamine-rich tetratricopeptide repeat-containing protein alpha |
| NCBI Synonym Full Names: | small glutamine rich tetratricopeptide repeat containing alpha |
| NCBI Official Symbol: | SGTA |
| NCBI Official Synonym Symbols: | SGT; hSGT; alphaSGT |
| NCBI Protein Information: | small glutamine-rich tetratricopeptide repeat-containing protein alpha |
| UniProt Protein Name: | Small glutamine-rich tetratricopeptide repeat-containing protein alpha |
| UniProt Synonym Protein Names: | Alpha-SGT; Vpu-binding protein; UBP |
| Protein Family: | Small glutamine-rich tetratricopeptide repeat-containing protein |
| UniProt Gene Name: | SGTA |
| UniProt Entry Name: | SGTA_HUMAN |
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