Human SFTPD Recombinant Protein (RPPB4664)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB4664
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SFTPD
Synonyms:
Surfactant Protein D
Synonyms:
SFTP4
Synonyms:
Surfactant Pulmonary-Associated Protein D
Synonyms:
Lung Surfactant Protein D
Source:
Escherichia Coli
Uniprot:
P35247
€0.00
Frequently bought together:

Description

Product Name:Human SFTPD Recombinant Protein
Product Code:RPPB4664
Size:20µg
Species:Human
Target:SFTPD
Synonyms:Surfactant Protein D, SFTP4, Surfactant Pulmonary-Associated Protein D, Lung Surfactant Protein D, Collectin-7, COLEC7, PSP-D, SP-D, Surfactant-Associated Protein Pulmonary 4, Pulmonary Surfactant-Associated Protein D, Pulmonary Surfactant Apoprotein, Collectin 7, PSPD, SFTPD.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SFTPD protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSVASLRQQ VEALQGQVQH LQAAFSQYKK VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED CVEIFTNGKW NDRACGEKRL VVCEF

Surfactant pulmonary-associated protein D (SFTPD) belongs to the collectin family of C-type lectins, which is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. SFTPD has humoral molecules of the innate immune system, and is deemed a functional candidate in chronic periodontitis. Moreover, SFTPD is involved in the development of acute and chronic inflammation of the lung. A number of human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. SFTPD contributes to the lungs defense against inhaled microorganisms, organic antigens and toxins. SFTPD interacts with complexes such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. In addition, SFTPD participates in the extracellular reorganization or turnover of pulmonary surfactant. SFTPD binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

SFTPD Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 175 amino acids (224-375 a.a) and having a molecular mass of 18.9kDa.SFTPD is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SFTPD: Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. Belongs to the SFTPD family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10q22.2-q23.1

Cellular Component: proteinaceous extracellular matrix; extracellular space; collagen; lysosome; endocytic vesicle; extracellular region

Molecular Function:protein binding; carbohydrate binding

Biological Process: receptor-mediated endocytosis; negative regulation of T cell proliferation; positive regulation of phagocytosis; defense response to bacterium; negative regulation of interleukin-2 biosynthetic process; innate immune response; respiratory gaseous exchange; surfactant homeostasis; macrophage chemotaxis; alveolus development; regulation of cytokine production

NCBI Summary:The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]
UniProt Code:P35247
NCBI GenInfo Identifier:317373510
NCBI Gene ID:6441
NCBI Accession:P35247.3
UniProt Secondary Accession:P35247,Q5T0M3, Q6FH08, Q86YK9, Q8TCD8, Q9UCJ2, Q9UCJ3
UniProt Related Accession:P35247
Molecular Weight:37,728 Da
NCBI Full Name:Pulmonary surfactant-associated protein D
NCBI Synonym Full Names:surfactant protein D
NCBI Official Symbol:SFTPD  
NCBI Official Synonym Symbols:SP-D; PSP-D; SFTP4; COLEC7  
NCBI Protein Information:pulmonary surfactant-associated protein D
UniProt Protein Name:Pulmonary surfactant-associated protein D
UniProt Synonym Protein Names:Collectin-7; Lung surfactant protein D
UniProt Gene Name:SFTPD  
UniProt Entry Name:SFTPD_HUMAN
View AllClose

Related Products