Human SERPINC1 Recombinant Protein (RPPB4641)
- SKU:
- RPPB4641
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- SERPINC1
- Synonyms:
- AT3
- AT3D
- ATIII
- THPH7
- Source:
- Escherichia Coli
- Uniprot:
- P01008
Description
| Product Name: | Human SERPINC1 Recombinant Protein |
| Product Code: | RPPB4641 |
| Size: | 20µg |
| Species: | Human |
| Target: | SERPINC1 |
| Synonyms: | AT3, AT3D, ATIII, THPH7, Antithrombin-III, Serpin C1, SERPINC1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | SERPINC1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHGSPVDI CTAKPRDIPM NPMCIYRSPE KKATEDEGSE QKIPEATNRR VWELSKANSR FATTFYQHLA DSKNDNDNIF LSPLSISTAF AMTKLGACND TLQQLMEVFK FDTISEKTSD QIHFFFAKLN CRLYRKANKS SKLVSANRLF GDKSLTFNET YQDISELVYG AKLQPLDFKE NAEQSRAAIN KWVSNKTEGR ITDVIPSEAI NELTVLVLVN TIYFKGLWKS KFSPENTRKE LFYKADGESC SASMMYQEGK FRYRRVAEGT QVLELPFKGD DITMVLILPK PEKSLAKVEK ELTPEVLQEW LDELEEMMLV VHMPRFRIED GFSLKEQLQD MGLVDLFSPE KSKLPGIVAE GRDDLYVSDA FHKAFLEVNE EGSEAAASTA VVIAGRSLNP NRVTFKANRP FLVFIREVPL NTIIFMGRVA NPCVK |
Serpin Peptidase Inhibitor, Clade C Member 1 (SERPINC1), which is a part of the serpin superfamily, is a plasma protease inhibitor. SERPINC1 inhibits thrombin and other activated serine proteases of the coagulation system, and regulates the blood coagulation cascade. SERPINC1 also inhibits Thrombin and Factors IXa, Xa and XIa. Deficiencies in SERPINC1 can cause ATIII deficiency, an autosomal dominant disease which might lead to a hereditary thrombophilia.
SERPINC1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 455 amino acids (33-464 a.a) and having a molecular mass of 51.4kDa. SERPINC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SERPINC1: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D). AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin- binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Belongs to the serpin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Inhibitor Chromosomal Location of Human Ortholog: 1q25.1 Cellular Component: extracellular space; plasma membrane; extracellular region Molecular Function:heparin binding; serine-type endopeptidase inhibitor activity; protein binding; protease binding Biological Process: negative regulation of inflammatory response; blood coagulation; response to nutrient Disease: Antithrombin Iii Deficiency |
| NCBI Summary: | The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009] |
| UniProt Code: | P01008 |
| NCBI GenInfo Identifier: | 113936 |
| NCBI Gene ID: | 462 |
| NCBI Accession: | P01008.1 |
| UniProt Secondary Accession: | P01008,P78439, P78447, Q13815, Q5TC78, Q7KZ43, Q7KZ97 Q9UC78, B2R6P0, |
| UniProt Related Accession: | P01008 |
| Molecular Weight: | 464 |
| NCBI Full Name: | Antithrombin-III |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade C (antithrombin), member 1 |
| NCBI Official Symbol: | SERPINC1 |
| NCBI Official Synonym Symbols: | AT3; AT3D; ATIII; THPH7 |
| NCBI Protein Information: | antithrombin-III; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 |
| UniProt Protein Name: | Antithrombin-III |
| UniProt Synonym Protein Names: | Serpin C1 |
| UniProt Gene Name: | SERPINC1 |
| UniProt Entry Name: | ANT3_HUMAN |
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