Human SERPINB3 Recombinant Protein (RPPB4636)

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SKU:
RPPB4636
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
SERPINB3
Synonyms:
Serpin B3
Synonyms:
Squamous cell carcinoma antigen 1
Synonyms:
ProteinT4-A
Synonyms:
SCCA-1
Source:
Escherichia Coli
Uniprot:
P29508
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Description

Product Name:Human SERPINB3 Recombinant Protein
Product Code:RPPB4636
Size:20µg
Species:Human
Target:SERPINB3
Synonyms:Serpin B3, Squamous cell carcinoma antigen 1, ProteinT4-A, SCCA-1, Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3, SCCA1, Serine (Or Cysteine) Proteinase Inhibitor, Clade B(Ovalbumin), Member 3, Squamous Cell Carcinoma Antigen 1, Protein T4-A, SCCA-1,Serpin B3, HsT1196, SCCA-PD, T4-A , SCCA, SCC.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:SERPINB3 protein solution (0.5mg/ml) containing Phosphatebuffered saline (pH7.4),10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMNSLSEA NTKFMFDLFQ QFRKSKENNI FYSPISITSA LGMVLLGAKDNTAQQIKKVL HFDQVTENTT GKAATYHVDR SGNVHHQFQK LLTEFNKSTD AYELKIANKL FGEKTYLFLQEYLDAIKKFY QTSVESVDFA NAPEESRKKI NSWVESQTNE KIKNLIPEGN IGSNTTLVLV NAIYFKGQWEKKFNKEDTKE EKFWPNKNTY KSIQMMRQYT SFHFASLEDV QAKVLEIPYK GKDLSMIVLL PNEIDGLQKLEEKLTAEKLM EWTSLQNMRE TRVDLHLPRF KVEESYDLKD TLRTMGMVDI FNGDADLSGM TGSRGLVLSGVLHKAFVEVT EEGAEAAAAT AVVGFGSSPT STNEEFHCNH PFLFFIRQNK TNSILFYGRF SSP

SerpinPeptidase Inhibitor, Clade B Member 3, also known as SERPINB3 is a papain-likecysteine protease inhibitor which modulates the host immune response versus tumorcells. SERPINB3 is a protein coding gene which acts as an inhibitor of UV-inducedapoptosis by suppressing the activity of c-Jun NH(2)-terminal kinase (JNK1).

SERPINB3 Human Recombinant produced in E.Coli is asingle, non-glycosylated polypeptide chain containing 413 amino acids (1-390 a.a)and having a molecular mass of 47kDa. SERPINB3 is fused to a 23 amino acid His-tag atN-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:SERPINB3: May act as a protease inhibitor to modulate the host immune response against tumor cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 18q21.3

Cellular Component: cytoplasm; cytoplasmic vesicle; extracellular space; nucleus; vesicle

Molecular Function:cysteine protease inhibitor activity; protease binding; serine-type endopeptidase inhibitor activity; viral receptor activity

Biological Process: negative regulation of catalytic activity; negative regulation of JNK activity; negative regulation of peptidase activity; negative regulation of proteolysis; positive regulation of cell migration; positive regulation of cell proliferation

UniProt Code:P29508
NCBI GenInfo Identifier:20141712
NCBI Gene ID:6317
NCBI Accession:P29508.2
UniProt Secondary Accession:P29508,Q53H28, Q53YB5, Q86VF3, Q86W04, Q8IWL4, Q8IXI3 Q96J21, Q9BYF8, A6NDM2, B2RBT5, B3W5Y6,
UniProt Related Accession:P29508
Molecular Weight:38,550 Da
NCBI Full Name:Serpin B3
NCBI Synonym Full Names:serpin family B member 3
NCBI Official Symbol:SERPINB3  
NCBI Official Synonym Symbols:SCC; T4-A; SCCA1; SSCA1; SCCA-1; HsT1196; SCCA-PD  
NCBI Protein Information:serpin B3
UniProt Protein Name:Serpin B3
UniProt Synonym Protein Names:Protein T4-A; Squamous cell carcinoma antigen 1; SCCA-1
Protein Family:Serpin
UniProt Gene Name:SERPINB3  
UniProt Entry Name:SPB3_HUMAN
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