Human SERPINA4 Recombinant Protein (RPPB4628)

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SKU:
RPPB4628
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SERPINA4
Synonyms:
Serpin Peptidase Inhibitor
Synonyms:
Clade A (Alpha-1 Antiproteinase
Synonyms:
Antitrypsin) Member 4
Synonyms:
PI4
Source:
HEK293 Cells
Uniprot:
P29622
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Description

Product Name:Human SERPINA4 Recombinant Protein
Product Code:RPPB4628
Size:10µg
Species:Human
Target:SERPINA4
Synonyms:Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin) Member 4, PI4, KST, Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4, Peptidase Inhibitor 4, Kallikrein Inhibitor, Serpin A4, PI-4, Protease Inhibitor 4 (Kallistatin), Kallistatin, KLST, KAL, SERPINA4.
Source:HEK293 Cells
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:SERPINA4 was filtered (0.4µm) and lyophilized from 0.5mg/ml solution in phosphate buffered saline pH 7.4 and 5% (w/v) Trehalose.
Solubility:It is recommended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. SERPINA4 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:QLHVEHDGES CSNSSHQQIL ETGEGSPSLK IAPANADFAF RFYYLIASET PGKNIFFSPL SISAAYAMLS LGACSHSRSQ ILEGLGFNLT ELSESDVHRG FQHLLHTLNL PGHGLETRVG SALFLSHNLK FLAKFLNDTM AVYEAKLFHT NFYDTVGTIQ LINDHVKKET RGKIVDLVSE LKKDVLMVLV NYIYFKALWE KPFISSRTTP KDFYVDENTT VRVPMMLQDQ EHHWYLHDRY LPCSVLRMDY KGDATVFFIL PNQGKMREIE EVLTPEMLMR WNNLLRKRNF YKKLELHLPK FSISGSYVLD QILPRLGFTD LFSKWADLSG ITKQQKLEAS KSFHKATLDV DEAGTEAAAA TSFAIKFFSA QTNRHILRFN RPFLVVIFST STQSVLFLGK VVDPTKPHHH HHHHHHH

Kallistatin (SERPINA4) inhibits human amidolytic and kininogenase activities of tissue kallikrein. This inhibition is attained by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and production of a small C-terminal fragment of the inhibitor as a result of cleavage at the reactive site by tissue kallikrein.

SERPINA4 Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain (Gln21-Pro427) containing a total of 417 amino acids, having a calculated molecular mass of 47.7kDa and fused to a 10 aa His tag at C-Terminus.

UniProt Protein Function:SERPINA4: Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein. Belongs to the serpin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.13

Cellular Component: extracellular space

Molecular Function:serine-type endopeptidase inhibitor activity

UniProt Code:P29622
NCBI GenInfo Identifier:68067608
NCBI Gene ID:5267
NCBI Accession:P29622.3
UniProt Secondary Accession:P29622,Q53XB5, Q86TR9, Q96BZ5,
UniProt Related Accession:P29622
Molecular Weight:48,542 Da
NCBI Full Name:Kallistatin
NCBI Synonym Full Names:serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
NCBI Official Symbol:SERPINA4  
NCBI Official Synonym Symbols:KAL; KST; PI4; KLST; PI-4; kallistatin  
NCBI Protein Information:kallistatin; serpin A4; kallikrein inhibitor; peptidase inhibitor 4; protease inhibitor 4 (kallistatin); serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
UniProt Protein Name:Kallistatin
UniProt Synonym Protein Names:Kallikrein inhibitor; Peptidase inhibitor 4; PI-4; Serpin A4
Protein Family:Kallistatin
UniProt Gene Name:SERPINA4  
UniProt Entry Name:KAIN_HUMAN
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