SCN3B (sodium channel; voltage-gated; type III; beta ;human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B family. It contains 1 Ig-like C2-type (immunoglobulin-like) domain. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B gene encodes one member of the sodium channel beta subunit gene family; and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants; encoding the same protein; have been identified. Defects in SCN3B are the cause of Brugada syndrome type 7. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram. It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation); the individual will faint and may die in a few minutes if the heart is not reset.
Product Name:
Human SCN3B Recombinant Protein (RPES4915)
Product Code:
RPES4915
Size:
20µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
ATFB16,BRGDA7,HSA243396,SCNB3
Accession:
Q9NY72
Sequence:
Met 1-Glu159
Fusion tag:
C-His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the mature form of human SCN3B (Q9NY72) extracellular domain (Met1-Glu159) was expressed with a polyhistidine tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
17.2 kDa
AP Mol Mass:
29 and 34 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
