Human Sclerostin/SOST Recombinant Protein (RPES4065)

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SKU:
RPES4065
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Description

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Human Sclerostin/SOST Recombinant Protein

Sclerostin, also known as SOST, is a member of the Cerberus/DAN family of BMP antagonists. SOST is asecreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain. It shows sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. SOST is produced by the osteocyte and has anti-anabolic effects on bone formation. It is a negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

Product Name:Human Sclerostin/SOST Recombinant Protein (RPES4065)
Product Code:RPES4065
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:CDD,DAND6,SOST1,VBCH
Accession:Q9BQB4
Sequence:Gln24-Tyr213
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Sclerostin is produced by our Mammalian expression system and the target gene encoding Gln24-Tyr213 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:22.3 kDa
AP Mol Mass:30 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM Tris, 250mM NaCl, pH 8.0.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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