Human SCGB2A2 Recombinant Protein (RPPB4592)

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SKU:
RPPB4592
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SCGB2A2
Synonyms:
Mammaglobin-A
Mammaglobin-1
Secretoglobin family 2A member 2
SCGB2A2
Source:
HEK293 Cells
Uniprot:
Q13296
Frequently bought together:

Description

Product Name:Human SCGB2A2 Recombinant Protein
Product Code:RPPB4592
Size:10µg
Species:Human
Target:SCGB2A2
Synonyms:Mammaglobin-A, Mammaglobin-1, Secretoglobin family 2A member 2, SCGB2A2, MGB1, UGB2, MGC71974.
Source:HEK293 Cells
Physical Appearance:Sterile filtered lyophilized powder.
Formulation:SCGB2A2 was filtered (0,4µm) and lyophilized from 0.5mg/ml in PBS buffer and 5% (w/v) Threalose pH 7.4 
Solubility:It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for 5 days.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:GSGCPLLENV ISKTINPQVS KTEYKELLQE FIDDNATTNA IDELKECFLN QTDETLSNVE VFMQLIYDSS LCDLF KLENL YFQGPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H

The mammaglobin gene was first identified using a differential screening approach directed at the isolation of novel, human breast cancer-associated genes. Mammaglobin encodes a 10 kDa glycoprotein and is distantly relaetd to a family of epithelial secretory proteins that includes rat estramustine-binding protein/prostatein and human Clara cell 10 kDa protein (CC10)/uteroglobin. Mammaglobin, a mammary-specific member of the uterglobin family, is known to be overexpressed in human breast cancer. Studies suggest that mammaglobin is one of the first relatively mammary-specific and mammary-sensitive markers (85%). Mammaglobin may be valuable used in a panel with BRST-2 (GCDFP-15) and ER in evaluating tumors of unknown primary sites.SCGB2A2 (the mammaglobin gene) is located on chromosome 11, at locus 11q13. SCGB2A2 is member of the secretoglobin superfamily of which is a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins appear to be involved in cell signalling, immune response, chemotaxis, and might also serve as transporters for steroid hormones in humans.

Mammaglobin-A Human Recombinant (Fc Chimera) produced in HEK cells is a single, glycosylated, polypeptide chain (Gly19-Phe93) containing a total of 321 amino acids, having a calculated molecular mass of 36.3kDa. The SCGB2A2 protein is fused to a 2 aa C-terminal linker, a 6 aa C-terminal His tag, a 7 aa TEV site and a 231 aa Human IgG1 fragment (Pro100-Lys330).

UniProt Protein Function:SCGB2A2: Belongs to the secretoglobin family. Lipophilin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 11q13

Molecular Function:protein binding

UniProt Code:Q13296
NCBI GenInfo Identifier:2833243
NCBI Gene ID:4250
NCBI Accession:Q13296.1
UniProt Secondary Accession:Q13296,Q86WH8, A1A522,
UniProt Related Accession:Q13296
Molecular Weight:10,122 Da
NCBI Full Name:Mammaglobin-A
NCBI Synonym Full Names:secretoglobin family 2A member 2
NCBI Official Symbol:SCGB2A2  
NCBI Official Synonym Symbols:MGB1; UGB2  
NCBI Protein Information:mammaglobin-A
UniProt Protein Name:Mammaglobin-A
UniProt Synonym Protein Names:Mammaglobin-1; Secretoglobin family 2A member 2
Protein Family:Secretoglobin family
UniProt Gene Name:SCGB2A2  
UniProt Entry Name:SG2A2_HUMAN

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