Human SCG5 Recombinant Protein (RPPB4589)

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SKU:
RPPB4589
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
SCG5
Synonyms:
7B2
Synonyms:
SgV
Synonyms:
P7B2
Synonyms:
SGNE1
Source:
Escherichia Coli
Uniprot:
P05408
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Description

Product Name:Human SCG5 Recombinant Protein
Product Code:RPPB4589
Size:10µg
Species:Human
Target:SCG5
Synonyms:7B2, SgV, P7B2, SGNE1, Secretogranin-5, Secretory granule endocrine protein I.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless liquid formulation.
Formulation:FABP3 His-Tag 0.5mg/ml protein solution is supplied in 20mM Tris-HCl pH-8, 0.1mM PMSF, 1mM DTT, 0.1M NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MYSPRTPDRV SEADIQRLLH GVMEQLGIAR PRVEYPAHQA MNLVGPQSIE GGAHEGLQHL GPFGNIPNIV AELTGDNIPK DFSEDQGYPDPPNPCPVGKT ADDGCLENTP DTAEFSREFQ LHQHLSDPEH DYPGLGKWNK KLLYEKMKGG ERRKRRSVNP YLQGQRLDNV VAKKSVPHFS DEDKDPELEH HHHHH

SCG5 also called 7B2 protein is localized in neuroendocrine tissues. SCG5 functions as a chaperone protein for the proprotein convertase PC2 and is essential for the production of an active PC2 enzyme.

SCG5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 195 amino acids (27-212 a.a.) and having a molecular mass of 22 kDa. SCG5 is fused to a 8 amino acid His tag at C-terminus and purified by standard chromatography techniques.

UniProt Protein Function:7B2: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. Belongs to the 7B2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Chaperone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q13-q14

Cellular Component: extracellular region; secretory granule

Molecular Function:enzyme inhibitor activity; protein binding; GTP binding; unfolded protein binding

Biological Process: intracellular protein transport; neuropeptide signaling pathway; negative regulation of catalytic activity; peptide hormone processing; regulation of hormone secretion

UniProt Code:P05408
NCBI GenInfo Identifier:23830842
NCBI Gene ID:6447
NCBI Accession:P05408.2
UniProt Secondary Accession:P05408,P01164, Q6FHD0, Q9BS38,
UniProt Related Accession:P05408
Molecular Weight:212
NCBI Full Name:Neuroendocrine protein 7B2
NCBI Synonym Full Names:secretogranin V (7B2 protein)
NCBI Official Symbol:SCG5  
NCBI Official Synonym Symbols:7B2; SgV; P7B2; SGNE1  
NCBI Protein Information:neuroendocrine protein 7B2; secretogranin-5; pituitary polypeptide; prohormone convertase chaperone; secretory granule endocrine protein I; secretory granule, neuroendocrine protein 1 (7B2 protein)
UniProt Protein Name:Neuroendocrine protein 7B2
UniProt Synonym Protein Names:Pituitary polypeptide; Secretogranin V; Secretogranin-5; Secretory granule endocrine protein ICleaved into the following 2 chains:N-terminal peptide; C-terminal peptide
Protein Family:Neuroendocrine protein
UniProt Gene Name:SCG5  
UniProt Entry Name:7B2_HUMAN
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