Human S100P Recombinant Protein (RPPB4578)

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SKU:
RPPB4578
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
S100P
Synonyms:
Protein S100-E
Synonyms:
S100E
Synonyms:
Migration-Inducing Gene 9
Synonyms:
MIG9
Source:
Escherichia Coli
Uniprot:
P25815
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Description

Product Name:Human S100P Recombinant Protein
Product Code:RPPB4578
Size:25µg
Species:Human
Target:S100P
Synonyms:Protein S100-E, S100E, Migration-Inducing Gene 9, MIG9.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:S100P Human solution (1mg/ml) containing 20mM Tris-HCl pH-8, 1mM DTT, 0.05M NaCl & 20% glycerol. 
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MTELETAMGM IIDVFSRYSG SEGSTQTLTK GELKVLMEKE LPGFLQSGKD KDAVDKLLKD LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK

S100P is a Ca2+ binding protein that is part of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are found in the cytoplasm and/or nucleus of a large range of cells, and participates in the regulation of a number of cellular function such as cell cycle progression and differentiation. S100P participates in numerous biological functions but the exact functions or mechanism of its action is still mostly unknown. Once S100P binds calcium ions it goes through a conformational change that results in an exposure of a hydrophobic surface which permits the interaction with specific target proteins.

S100P Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 115 amino acids (1-95a.a.) and having a molecular mass of 12.6 kDa. S100P protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

UniProt Protein Function:May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE).
NCBI Summary:The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008]
UniProt Code:P25815
NCBI GenInfo Identifier:134142
NCBI Gene ID:6286
NCBI Accession:P25815.2
UniProt Secondary Accession:P25815,Q5J7W2,
UniProt Related Accession:P25815
Molecular Weight:10,400 Da
NCBI Full Name:Protein S100-P
NCBI Synonym Full Names:S100 calcium binding protein P
NCBI Official Symbol:S100P  
NCBI Official Synonym Symbols:MIG9  
NCBI Protein Information:protein S100-P
UniProt Protein Name:Protein S100-P
UniProt Synonym Protein Names:Migration-inducing gene 9 protein; MIG9; Protein S100-E; S100 calcium-binding protein P
Protein Family:Protein
UniProt Gene Name:S100P  
UniProt Entry Name:S100P_HUMAN
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