The calcium-binding Protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21; and S100 proteins consisting of at least 20 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100A2 was first detected in lung and kidney; and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S100A2 protein is a homodimer that undergoes a conformational change upon binding of calcium; and the active form functions in regulating cell proliferation and differentiation; gene transcription; and p53-dependent growth arrest and apoptosis. Accordingly; this protein is regarded as a putative tumor suppressor; and thus chromosomal rearrangements and reduced expression of S100A2 gene have been implicated in certain carcinomas.
Product Name:
Human S100A2 Recombinant Protein (RPES0800)
Product Code:
RPES0800
Size:
20µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
Protein S100-A2, CAN19, Protein S-100L, S100 calcium-binding protein A2, S100A2, S100L
Accession:
NP_005969.1
Sequence:
Met 2-Pro98
Fusion tag:
N-Fc
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human S100A2 (NP_005969.1) (Met 2-Pro98) was expressed with the fused Fc region of human IgG1 at the N-terminus.
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
