Human S100A14 Recombinant Protein (RPPB4551)

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SKU:
RPPB4551
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
S100A14
Synonyms:
Protein S100-A14
Synonyms:
S100 calcium-binding protein A14
Synonyms:
S114
Synonyms:
S100A14
Source:
Escherichia Coli
Uniprot:
Q9HCY8
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Description

Product Name:Human S100A14 Recombinant Protein
Product Code:RPPB4551
Size:10µg
Species:Human
Target:S100A14
Synonyms:Protein S100-A14, S100 calcium-binding protein A14, S114, S100A14, S100A15, BCMP84.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The S100A14 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGQCRSANAE DAQEFSDVER AIETLIKNFH QYSVEGGKET LTPSELRDLV TQQLPHLMPS NCGLEEKIAN LGSCNDSKLE FRSFWELIGE AAKSVKLERP VRGH

S100A14 belongs to a subfamily of proteins related by EF-hand Ca2+ binding protein superfamily. The extracellular functions of the S100 family include the ability to boost neurite outgrowth, involvement in inflammation, and motility of tumor cells. S100A14 contains 2 EF-hand Ca2+-binding domains, a myristoylation motif, a glycosylation site, and a number of potential protein kinase phosphorylation sites. S100A14 is expressed at high levels in the colon and at moderate levels in the thymus, kidney, liver, small intestine, and lung.

S100A14 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 124 amino acids (1-104 a.a.) and having a molecular mass of 13.8kDa. The S100A14 is purified by proprietary chromatographic techniques.

UniProt Protein Function:S100A14: a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cell junction; cytosol; nuclear body; perinuclear region of cytoplasm

Molecular Function:chemokine receptor binding; protein binding

Biological Process: defense response to bacterium; response to lipopolysaccharide; toll-like receptor 4 signaling pathway

NCBI Summary:This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]
UniProt Code:Q9HCY8
NCBI GenInfo Identifier:20178118
NCBI Gene ID:57402
NCBI Accession:Q9HCY8.1
UniProt Secondary Accession:Q9HCY8,Q5RHT0,
UniProt Related Accession:Q9HCY8
Molecular Weight:12kDa
NCBI Full Name:Protein S100-A14
NCBI Synonym Full Names:S100 calcium binding protein A14
NCBI Official Symbol:S100A14  
NCBI Official Synonym Symbols:BCMP84; S100A15  
NCBI Protein Information:protein S100-A14
UniProt Protein Name:Protein S100-A14
UniProt Synonym Protein Names:S100 calcium-binding protein A14; S114
Protein Family:Protein
UniProt Gene Name:S100A14  
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