Human S100A11 Recombinant Protein (RPPB4548)

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SKU:
RPPB4548
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
S100A11
Synonyms:
Protein S100-A11
Synonyms:
S100 calcium-binding protein A11
Synonyms:
Calgizzarin
Synonyms:
MLN 70
Source:
Escherichia Coli
Uniprot:
P31949
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Description

Product Name:Human S100A11 Recombinant Protein
Product Code:RPPB4548
Size:10µg
Species:Human
Target:S100A11
Synonyms:Protein S100-A11, S100 calcium-binding protein A11, Calgizzarin, MLN 70, S100A11, MLN70, S100C.
Source:Escherichia Coli
Formulation:S100A11 is supplied in PBS and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE. 2 bands on Western blot at 17 and 34 kDa, respectively representing monomeric and dimeric form.

S100A11 is a member of the S100 family of proteins which contains two EF-hand calcium-binding motifs and is thought to be involved in the regulation of a number of cellular processes including cell cycle progression and differentiation. S100A11 may function in motility, invasion and tubulin polymerisation. S100 proteins are localized either in the cytoplasm or the nucleus of a wide range of cells. There are at least 13 members in the S100 gene family, which are located as a cluster on chromosome 1q21. Chromosomal rearrangements and altered expression of S100A11 have been implicated in tumor metastasis.

S100A11 Human Recombinant is expressed in E. coli having a molecular weight of 17kDa fused to an amino terminal hexahistidine tag.

UniProt Protein Function:S100A11: a calcium-binding regulatory protein of the S-100 family. Interacts with the N-termini of annexins A1. May regulate fusion processes such as endo- and exocytosis. Increases in the early stage of pancreatic carcinogenesis and decreases during subsequent progression to cancer. Increased expression in anaplastic large cell lymphoma.
UniProt Protein Details:

Protein type:Calcium-binding; DNA replication; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; extracellular space; nucleus; ruffle

Molecular Function:calcium-dependent protein binding; protein binding; protein homodimerization activity

Biological Process: negative regulation of cell proliferation; negative regulation of DNA replication; signal transduction

NCBI Summary:The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008]
UniProt Code:P31949
NCBI GenInfo Identifier:1710818
NCBI Gene ID:6282
NCBI Accession:P31949.2
UniProt Secondary Accession:P31949,Q5VTK0,
UniProt Related Accession:P31949
Molecular Weight:11,740 Da
NCBI Full Name:Protein S100-A11
NCBI Synonym Full Names:S100 calcium binding protein A11
NCBI Official Symbol:S100A11  
NCBI Official Synonym Symbols:MLN70; S100C; HEL-S-43  
NCBI Protein Information:protein S100-A11
UniProt Protein Name:Protein S100-A11
UniProt Synonym Protein Names:Calgizzarin; Metastatic lymph node gene 70 protein; MLN 70
Protein Family:Protein
UniProt Gene Name:S100A11  
UniProt Entry Name:S10AB_HUMAN
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