Human RPL34 Recombinant Protein (RPPB4498)
- SKU:
- RPPB4498
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- RPL34
- Synonyms:
- Ribosomal Protein L34
- 60S Ribosomal Protein L34
- Leukemia-Associated Protein
- L34
- Source:
- Escherichia Coli
- Uniprot:
- P49207
Description
| Product Name: | Human RPL34 Recombinant Protein |
| Product Code: | RPPB4498 |
| Size: | 20µg |
| Species: | Human |
| Target: | RPL34 |
| Synonyms: | Ribosomal Protein L34, 60S Ribosomal Protein L34, Leukemia-Associated Protein, L34. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The RPL34 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMVQRLTY RRRLSYNTAS NKTRLSRTPG NRIVYLYTKK VGKAPKSACG VCPGRLRGVR AVRPKVLMRL SKTKKHVSRA YGGSMCAKCV RDRIKRAFLI EEQKIVVKVL KAQAQSQKAK |
Ribosomes, the organelles which catalyze protein synthesis, contain a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and nearly 80 structurally different proteins. RPL34 is a member of the L34E family of ribosomal proteins and it encodes a ribosomal protein which is a component of the 60S subunit. RPL34 is found in the cytoplasm and has been mapped to 4q though it was initially believed it is located at 17q21. Transcript variants which are a result of alternative splicing, alternative transcription initiation sites, and/or alternative polyadenylation exist; all encode the same protein. As is typical for genes encoding ribosomal proteins, there are several processed pseudogenes of this gene spread all over the genome.
RPL34 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 140 amino acids (1-117) and having a molecular mass of 15.7kDa.RPL34 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RPL34: a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Transcript variants derived from alternative splicing, alternative transcription initiation sites, and/or alternative polyadenylation exist; these variants encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Translation; Ribosomal Chromosomal Location of Human Ortholog: 4q25 Cellular Component: cytoplasm; cytosol; nucleolus Molecular Function:RNA binding Biological Process: mRNA catabolic process, nonsense-mediated decay; ribosome biogenesis and assembly; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translational initiation; viral transcription |
| NCBI Summary: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016] |
| UniProt Code: | P49207 |
| NCBI GenInfo Identifier: | 22002070 |
| NCBI Gene ID: | 6164 |
| NCBI Accession: | P49207.3 |
| UniProt Secondary Accession: | P49207,Q6FG66, Q9BUZ2, |
| UniProt Related Accession: | P49207 |
| Molecular Weight: | 13,293 Da |
| NCBI Full Name: | 60S ribosomal protein L34 |
| NCBI Synonym Full Names: | ribosomal protein L34 |
| NCBI Official Symbol: | RPL34 |
| NCBI Official Synonym Symbols: | L34 |
| NCBI Protein Information: | 60S ribosomal protein L34 |
| UniProt Protein Name: | 60S ribosomal protein L34 |
| Protein Family: | 50S ribosomal protein |
| UniProt Gene Name: | RPL34 |
| UniProt Entry Name: | RL34_HUMAN |
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