Human RGS19 Recombinant Protein (RPPB4452)

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SKU:
RPPB4452
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
RGS19
Synonyms:
GAIP
Regulator of G-protein signalling 19
G alpha interacting protein
GNAI3IP
Source:
Escherichia Coli
Uniprot:
P49795
Frequently bought together:

Description

Product Name:Human RGS19 Recombinant Protein
Product Code:RPPB4452
Size:20µg
Species:Human
Target:RGS19
Synonyms:GAIP, Regulator of G-protein signalling 19, G alpha interacting protein, GNAI3IP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The RGS19 protein solution (0.5mg/1ml) is formulated in Phosphate Buffered Saline (pH7.4) and 10% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MPTPHEAEKQ ITGPEEADRP PSMSSHDTAS PAAPSRNPCC LCWCCCCSCS WNQERRRAWQ ASRESKLQPL PSCEVCATPS PEEVQSWAQS FDKLMHSPAG RSVFRAFLRT EYSEENMLFW LACEELKAEA NQHVVDEKAR LIYEDYVSIL SPKEVSLDSR VREGINKKMQ EPSAHTFDDA QLQIYTLMHR DSYPRFLSSP TYRALLLQGP SQSSSEA

RGS19 is a member of RGS (regulator of G protein signaling) family and negatively regulates G protein coupled receptor signaling. RGS19 protein specifically cooperates with heterotrimeric GTP-binding protein G alpha i3 (GAI3).

RGS19 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-217a.a.) and having a molecular mass of 26.7kDa.RGS19 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RGS19: inhibits signal transduction by increasing the GTPase activity of g protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(I)a3 > G(I)a1 > G(O)a >> G(Z)a/G(I)a2. Activity on G(Z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
UniProt Protein Details:

Protein type:GAPs, RGS; GAPs

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: beta-catenin destruction complex; cell cortex; cytoplasmic membrane-bound vesicle; cytoplasmic microtubule; Golgi apparatus; heterotrimeric G-protein complex; membrane; postsynaptic density

Molecular Function:beta-catenin binding; GTPase activator activity; protein binding; protein kinase binding

Biological Process: cell death; cell differentiation; dorsal/ventral axis specification; G-protein coupled receptor protein signaling pathway; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction

NCBI Summary:G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P49795
NCBI GenInfo Identifier:1730186
NCBI Gene ID:10287
NCBI Accession:P49795.1
UniProt Secondary Accession:P49795,Q53XN0, Q8TD60, A8K216, E1P5G9,
UniProt Related Accession:P49795
Molecular Weight:24,636 Da
NCBI Full Name:Regulator of G-protein signaling 19
NCBI Synonym Full Names:regulator of G-protein signaling 19
NCBI Official Symbol:RGS19  
NCBI Official Synonym Symbols:GAIP; RGSGAIP  
NCBI Protein Information:regulator of G-protein signaling 19
UniProt Protein Name:Regulator of G-protein signaling 19
UniProt Synonym Protein Names:G-alpha-interacting protein; GAIP
Protein Family:Regulator of G-protein signaling
UniProt Gene Name:RGS19  
UniProt Entry Name:RGS19_HUMAN

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