Human REG4 Recombinant Protein (RPPB4439)

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SKU:
RPPB4439
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
REG4
Synonyms:
Regenerating islet-derived protein 4
Synonyms:
Reg IV
Synonyms:
REG-like protein
Synonyms:
Gastrointestinal secretory protein
Source:
Sf9 Insect cells
Uniprot:
Q9BYZ8
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Description

Product Name:Human REG4 Recombinant Protein
Product Code:RPPB4439
Size:10µg
Species:Human
Target:REG4
Synonyms:Regenerating islet-derived protein 4, Reg IV, REG-like protein, Gastrointestinal secretory protein, REG4, GISP, RELP.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:REG4 protein solution (0.25mg/ml) contains 10% glycerol & Phosphate buffered saline (pH7.4). 
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:ADPDIIMRPS CAPGWFYHKS NCYGYFRKLR NWSDAELECQ SYGNGAHLAS ILSLKEASTIAEYISGYQRS QPIWIGLHDP QKRQQWQWID GAMYLYRSWS GKSMGGNKHC AEMSSNNNFL TWSSNECNKR QHFLCKYRPH HHHHH

REG protein was shown to be stimulated during the regeneration of pancreatic islets. Since then, many Reg-related proteins have been identified in humans and other animals. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their amino-acid sequences, but they share a similar structure and physiological function. Reg protein is a growth factor for pancreatic beta cells and also suggests that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus. Human REG cDNA which encodes a 166-amino acid protein with a 22-amino acid signal peptide. The amino acid sequence of human REG protein has 68% homology to that of rat Reg protein.

REG4 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (23-158 a.a.) and fused to a 9 aa His Tag at C-terminus containing a total of 145 amino acids and having a molecular mass of 17kDa.REG4 shows multiple bands between 13.5-18kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.

UniProt Protein Function:REG4: Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p13.1-p12

Cellular Component: cytoplasm; extracellular region

Molecular Function:heparin binding; calcium ion binding

UniProt Code:Q9BYZ8
NCBI GenInfo Identifier:68565834
NCBI Gene ID:83998
NCBI Accession:Q9BYZ8.1
UniProt Secondary Accession:Q9BYZ8,Q8NER6, Q8NER7,
UniProt Related Accession:Q9BYZ8
Molecular Weight:14,993 Da
NCBI Full Name:Regenerating islet-derived protein 4
NCBI Synonym Full Names:regenerating islet-derived family, member 4
NCBI Official Symbol:REG4  
NCBI Official Synonym Symbols:GISP; RELP; REG-IV  
NCBI Protein Information:regenerating islet-derived protein 4; REG-4; reg IV; REG-like protein; regenerating gene type IV; gastrointestinal secretory protein; regenerating islet-derived protein IV
UniProt Protein Name:Regenerating islet-derived protein 4
UniProt Synonym Protein Names:Gastrointestinal secretory protein; REG-like protein; Regenerating islet-derived protein IV; Reg IV
Protein Family:Regenerating islet-derived protein
UniProt Gene Name:REG4  
UniProt Entry Name:REG4_HUMAN
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