Human RARRES2 Recombinant Protein (RPPB4410)

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SKU:
RPPB4410
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
RARRES2
Synonyms:
RetinoicAcid Receptor Responder 2
Synonyms:
Chemerin
Synonyms:
Retinoic Acid Receptor Responder(Tazarotene Induced) 2
Synonyms:
Tazarotene-Induced Gene 2 Protein
Source:
Sf9 Insect cells
Uniprot:
Q99969
€0.00
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Description

Product Name:Human RARRES2 Recombinant Protein
Product Code:RPPB4410
Size:5µg
Species:Human
Target:RARRES2
Synonyms:RetinoicAcid Receptor Responder 2, Chemerin, Retinoic Acid Receptor Responder(Tazarotene Induced) 2, Tazarotene-Induced Gene 2 Protein, RAR-ResponsiveProtein TIG2, TIG2, Retinoic Acid Receptor Responder Protein 2, HP10433, Retinoicacid receptor responder protein 2, Chemerin, RAR-responsive protein TIG2, Tazarotene-inducedgene 2 protein.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:RARRES2protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10%glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPELTEAQR RGLQVALEEFHKHPPVQWAF QETSVESAVD TPFPAGIFVR LEFKLQQTSC RKRDWKKPEC KVRPNGRKRK CLACIKLGSE DKVLGRLVHCPIETQVLREA EEHQETQCLR VQRAGEDPHS FYFPGQFAFS HHHHHH

RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 is upregulated by the synthetic retinoid tazarotene and found in a vast variety of tissues. RARRES2 acts as an adipokine, and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors, cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity, which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor, ChemR23 (CMKLR1), as a positive regulator of adipocyte differentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains. The Chemerin receptor has another ligand, called tazarotene-induced gene.

RARRES2 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 146 amino acids (21-157a.a.) andhaving a molecular mass of 16.9kDa. (Molecular size on SDS-PAGE will appear atapproximately 18-28kDa).RARRES2 is expressed with a6 amino acid His tag at C-Terminus and purified by proprietary chromatographictechniques.

UniProt Protein Function:RARRES2: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: extracellular matrix; extracellular region

Molecular Function:protein binding; receptor binding

Biological Process: cell differentiation; chemotaxis; embryonic gut development; in utero embryonic development; inflammatory response; positive regulation of chemotaxis; positive regulation of fat cell differentiation; positive regulation of protein amino acid phosphorylation; regulation of lipid catabolic process; retinoid metabolic process

NCBI Summary:This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]
UniProt Code:Q99969
NCBI GenInfo Identifier:6226227
NCBI Gene ID:5919
NCBI Accession:Q99969.1
UniProt Secondary Accession:Q99969,Q7LE02,
UniProt Related Accession:Q99969
Molecular Weight:18,618 Da
NCBI Full Name:Retinoic acid receptor responder protein 2
NCBI Synonym Full Names:retinoic acid receptor responder 2
NCBI Official Symbol:RARRES2  
NCBI Official Synonym Symbols:TIG2; HP10433  
NCBI Protein Information:retinoic acid receptor responder protein 2
UniProt Protein Name:Retinoic acid receptor responder protein 2
UniProt Synonym Protein Names:Chemerin; RAR-responsive protein TIG2; Tazarotene-induced gene 2 protein
Protein Family:Retinoic acid receptor responder protein
UniProt Gene Name:RARRES2  
UniProt Entry Name:RARR2_HUMAN
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