Human RARRES2 Recombinant Protein (RPPB4409)
- SKU:
- RPPB4409
- Product type:
- Recombinant Protein
- Size:
- 25ug
- Species:
- Human
- Target:
- RARRES2
- Synonyms:
- Chemerin
- TIG2
- Tazarotene-induced gene 2 protein
- Retinoic acid receptor responder protein 2
- Source:
- Escherichia Coli
- Uniprot:
- Q99969
Description
| Product Name: | Human RARRES2 Recombinant Protein |
| Product Code: | RPPB4409 |
| Size: | 25µg |
| Species: | Human |
| Target: | RARRES2 |
| Synonyms: | Chemerin, TIG2, Tazarotene-induced gene 2 protein, Retinoic acid receptor responder protein 2, RAR-responsive protein TIG2, RARRES2, HP10433. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | RARRES2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MELTEAQRRG LQVALEEFHK HPPVQWAFQE TSVESAVDTP FPAGIFVRLE FKLQQTSCRK RDWKKPECKV RPNGRKRKCL ACIKLGSEDK VLGRLVHCPI ETQVLREAEE HQETQCLRVQ RAGEDPHSFY FPGQFAFS |
RARRES2 is a secreted chemotactic protein that initiates chemotaxis through the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 is upregulated by the synthetic retinoid tazarotene and found in a vast variety of tissues. RARRES2 acts as an adipokine, and is truncated on both termini from the proprotein. RARRES2 is structurally related to the cathelicidin precursors, cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity, which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor, ChemR23 (CMKLR1), as a positive regulator of adipocyte differentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains. The Chemerin receptor has another ligand, called tazarotene-induced gene.
RARRES2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 158 amino acids (21-157a.a) and having a total molecular mass of 18 kDa. RARRES2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RARRES2: Inhibited in psoriatic lesions. Activated by tazarotene in skin rafts and in the epidermis of psoriatic lesions. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7q36.1 Cellular Component: extracellular matrix; extracellular region Molecular Function:protein binding; receptor binding Biological Process: cell differentiation; chemotaxis; embryonic gut development; in utero embryonic development; inflammatory response; positive regulation of chemotaxis; positive regulation of fat cell differentiation; positive regulation of protein amino acid phosphorylation; regulation of lipid catabolic process; retinoid metabolic process |
| NCBI Summary: | This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014] |
| UniProt Code: | Q99969 |
| NCBI GenInfo Identifier: | 6226227 |
| NCBI Gene ID: | 5919 |
| NCBI Accession: | Q99969.1 |
| UniProt Secondary Accession: | Q99969,Q7LE02, |
| UniProt Related Accession: | Q99969 |
| Molecular Weight: | 18,618 Da |
| NCBI Full Name: | Retinoic acid receptor responder protein 2 |
| NCBI Synonym Full Names: | retinoic acid receptor responder 2 |
| NCBI Official Symbol: | RARRES2 |
| NCBI Official Synonym Symbols: | TIG2; HP10433 |
| NCBI Protein Information: | retinoic acid receptor responder protein 2 |
| UniProt Protein Name: | Retinoic acid receptor responder protein 2 |
| UniProt Synonym Protein Names: | Chemerin; RAR-responsive protein TIG2; Tazarotene-induced gene 2 protein |
| Protein Family: | Retinoic acid receptor responder protein |
| UniProt Gene Name: | RARRES2 |
| UniProt Entry Name: | RARR2_HUMAN |
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