Human RAB34 Recombinant Protein (RPPB4361)

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SKU:
RPPB4361
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
RAB34
Synonyms:
RAB34 member RAS oncogene family
Synonyms:
RAH
Synonyms:
RAB39
Synonyms:
Ras-related protein Rab-39
Source:
Escherichia Coli
Uniprot:
P0DI83
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Description

Product Name:Human RAB34 Recombinant Protein
Product Code:RPPB4361
Size:10µg
Species:Human
Target:RAB34
Synonyms:RAB34 member RAS oncogene family, RAH, RAB39, Ras-related protein Rab-39, Ras-related protein Rah, ras-related protein Rab-34, NARR, Nine amino-acid residue-repeats.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The RAB34 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1M NaCl and 40% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MNILAPVRRD RVLAELPQCL RKEAALHGHK DFHPRVTCAC QEHRTGTVGF KISKVIVVGD LSVGKTCLIN RFCKDTFDKN YKATIGVDFE MERFEVLGIP FSLQLWDTAG QERFKCIAST YYRGAQAIII VFNLNDVASL EHTKQWLADA LKENDPSSVL LFLVGSKKDL STPAQYALME KDALQVAQEM KAEYWAVSSL TGENVREFFF RVAALTFEAN VLAELEKSGA RRIGDVVRIN SDDSNLYLTA SKKKPTCCP

RAB34 protein which regulates a fast endocytic recycling pathway is restricted to the plasma membrane and endocytic compartments. RAB34 takes part in protein transport, specifically the redistribution of lysosomes to the peri-Golgi region. In fibroblasts, RAB34 protein was co-localized with actin to the membrane ruffles and membranes of moderately large vesicles close to the ruffles.

RAB34 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 279 amino acids (1-259) and having a molecular mass of 31.2 kDa.RAB34 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NARR: May interact with EIF5A and ERF1. 3 isoforms of the human protein are produced by alternative splicing
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: Golgi apparatus; Golgi cisterna; Golgi stack; perinuclear region of cytoplasm; phagocytic vesicle; vesicle

Molecular Function:GTP-dependent protein binding; protein binding; Ral GTPase binding

Biological Process: antigen processing and presentation; Golgi to plasma membrane protein transport; lysosome localization

NCBI Summary:This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016]
UniProt Code:P0DI83
NCBI GenInfo Identifier:347602360
NCBI Gene ID:83871
NCBI Accession:P0DI83.1
UniProt Secondary Accession:P0DI83,Q9BZG1,
UniProt Related Accession:Q9BZG1
Molecular Weight:21kDa
NCBI Full Name:Ras-related protein Rab-34, isoform NARR
NCBI Synonym Full Names:RAB34, member RAS oncogene family
NCBI Official Symbol:RAB34  
NCBI Official Synonym Symbols:RAH; NARR; RAB39  
NCBI Protein Information:ras-related protein Rab-34
UniProt Protein Name:Ras-related protein Rab-34, isoform NARR
UniProt Synonym Protein Names:Nine amino-acid residue-repeats
Protein Family:Ras-related protein
UniProt Gene Name:RAB34  
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