Human RAB27B Recombinant Protein (RPPB4356)
- SKU:
- RPPB4356
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- RAB27B
- Synonyms:
- Ras-related protein Rab-27B
- C25KG
- RAB27B
- Source:
- Escherichia Coli
- Uniprot:
- O00194
Description
| Product Name: | Human RAB27B Recombinant Protein |
| Product Code: | RPPB4356 |
| Size: | 20µg |
| Species: | Human |
| Target: | RAB27B |
| Synonyms: | Ras-related protein Rab-27B, C25KG, RAB27B. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RAB27B solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0) , 0.1M Nacl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR VVYNAQGPNG SSGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD LTSQQSFLNV RNWMSQLQAN AYCENPDIVL IGNKADLPDQ REVNERQARE LADKYGIPYF ETSAATGQNV EKAVETLLDL IMKRMEQCVE KTQIPDTVNG GNSGNLDGEK PPEKKCIC |
RAB27B is a member of the RAB family and is an important regulator of vesicular transport. RAB27B is expressed in pituitary tissue, but is more extensively expressed in brain and spleen. RAB27B may be functionally redundant to Rab27a, as it can salvage Rab27a mutants.
RAB27B Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 238 amino acids (1-218 a.a.) and having a molecular mass of 26.7kDa. The RAB27B is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RAB27B: May be involved in targeting uroplakins to urothelial apical membranes. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein, monomeric, Rab; G protein, monomeric Chromosomal Location of Human Ortholog: 18q21.2 Cellular Component: Golgi stack; melanosome; secretory granule; trans-Golgi network transport vesicle Molecular Function:GDP binding; GTP binding; GTPase activity; myosin V binding; protein binding; protein domain specific binding Biological Process: melanosome transport; positive regulation of exocytosis |
| NCBI Summary: | Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | O00194 |
| NCBI GenInfo Identifier: | 14917027 |
| NCBI Gene ID: | 5874 |
| NCBI Accession: | O00194.4 |
| UniProt Secondary Accession: | O00194,Q9BZB6, B2RAB0, |
| UniProt Related Accession: | O00194 |
| Molecular Weight: | 24,608 Da |
| NCBI Full Name: | Ras-related protein Rab-27B |
| NCBI Synonym Full Names: | RAB27B, member RAS oncogene family |
| NCBI Official Symbol: | RAB27B |
| NCBI Official Synonym Symbols: | C25KG |
| NCBI Protein Information: | ras-related protein Rab-27B |
| UniProt Protein Name: | Ras-related protein Rab-27B |
| UniProt Synonym Protein Names: | C25KG |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB27B |
| UniProt Entry Name: | RB27B_HUMAN |
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