Human QPRT Recombinant Protein (RPPB2238)

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SKU:
RPPB2238
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
QPRT
Synonyms:
Quinolinate phosphoribosyltransferase
Synonyms:
QPRTase
Synonyms:
QAPRTase
Source:
Escherichia Coli
Uniprot:
Q15274
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Description

Product Name:Human QPRT Recombinant Protein
Product Code:RPPB2238
Size:20µg
Species:Human
Target:QPRT
Synonyms:Quinolinate phosphoribosyltransferase , QPRTase, QAPRTase.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The QPRT solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MDAEGLALLL PPVTLAALVD SWLREDCPGL NYAALVSGAG PSQAALWAKS PGVLAGQPFF DAIFTQLNCQ VSWFLPEGSK LVPVARVAEV RGPAHCLLLG ERVALNTLAR CSGIASAAAA AVEAARGAGW TGHVAGTRKT TPGFRLVEKY GLLVGGAASH RYDLGGLVMV KDNHVVAAGG VEKAVRAARQ AADFALKVEV ECSSLQEAVQ AAEAGADLVL LDNFKPEELH PTATVLKAQF PSVAVEASGG ITLDNLPQFC GPHIDVISMG MLTQAAPALD FSLKLFAKEV APVPKIH

QPRT is a key enzyme in the catabolism of quinolinate. QPRT is in between the tryptophannicotinamide adenine dinucleotide (NAD) pathway, resulting in the production of nicotinic acid, carbon dioxide and pyrophosphate. Rise of QPRT levels in the brain is related to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

QPRT Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 317 amino acids (1-297 a.a.) and having a molecular mass of 32.9 kDa. The QPRT is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:QPRT: Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
UniProt Protein Details:

Protein type:Transferase; EC 2.4.2.19; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytoplasm; cytosol

Molecular Function:nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein homodimerization activity

Biological Process: NAD biosynthetic process; NAD metabolic process; protein oligomerization

NCBI Summary:This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Code:Q15274
NCBI GenInfo Identifier:296439291
NCBI Gene ID:23475
NCBI Accession:Q15274.3
UniProt Secondary Accession:Q15274,Q53XW7, Q96G22, Q9BSG6,
UniProt Related Accession:Q15274
Molecular Weight:30,846 Da
NCBI Full Name:Nicotinate-nucleotide pyrophosphorylase
NCBI Synonym Full Names:quinolinate phosphoribosyltransferase
NCBI Official Symbol:QPRT  
NCBI Official Synonym Symbols:QPRTase; HEL-S-90n  
NCBI Protein Information:nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Protein Name:Nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt Synonym Protein Names:Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase
Protein Family:Nicotinate-nucleotide pyrophosphorylase
UniProt Gene Name:QPRT  
UniProt Entry Name:NADC_HUMAN
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