Human PSPH Recombinant Protein (RPPB2639)

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SKU:
RPPB2639
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
PSPH
Synonyms:
Phosphoserine phosphatase
Synonyms:
EC 3133
Synonyms:
PSP
Synonyms:
O-phosphoserine phosphohydrolase
Source:
Escherichia Coli
Uniprot:
P78330
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Description

Product Name:Human PSPH Recombinant Protein
Product Code:RPPB2639
Size:20µg
Species:Human
Target:PSPH
Synonyms:Phosphoserine phosphatase, EC 3.1.3.3, PSP, O-phosphoserine phosphohydrolase, PSPase, L-3-phosphoserine phosphatase, PSPH.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The protein contains 20mM Hepes pH 7.5, 1mM DTT &100mM KCl2.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:MVSHSELRKL FYSADAVCFD VDSTVIREEG IDELAKICGV EDAVSEMTRR AMGGAVPFKA ALTERLALIQ PSREQVQRLI AEQPPHLTPG IRELVSRLQE RNVQVFLISG GFRSIVEHVA SKLNIPATNV FANRLKFYFN GEYAGFDETQ PTAESGGKGK VIKLLKEKFH FKKIIMIGDG ATDMEACPPA DAFIGFGGNV IRQQVKDNAK WYITDFVELL GELEE

Human Phosphoserine phosphatase (hPSP) is an important enzyme in the phosphorylated pathway of serine biosynthesis, which contributes a major portion of the endogenous L-serine. Similar to known L-3-phosphoserine phosphatases, it catalyzed the Mg2+-dependent hydrolysis of L-phosphoserine and an exchange reaction between L-serine and L-phosphoserine. Recently, its complex structures reveal that the open-closed environmental change of the active site, generated -helical bundle domain, is important to substrate by local rearrangement of the recognition and hydrolysis.

Phosphoserine Phosphatase Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids and having a molecular mass of 25 kDa. PSP was overexpressed in E. coli and purified by conventional chromatography.

UniProt Protein Function:Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.
NCBI Summary:The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:P78330
NCBI GenInfo Identifier:46249388
NCBI Gene ID:5723
NCBI Accession:NP_004568
UniProt Secondary Accession:P78330,Q7Z3S5, B2RCR5,
UniProt Related Accession:P78330
Molecular Weight:25,008 Da
NCBI Full Name:phosphoserine phosphatase
NCBI Synonym Full Names:phosphoserine phosphatase
NCBI Official Symbol:PSPH  
NCBI Official Synonym Symbols:PSP; PSPHD  
NCBI Protein Information:phosphoserine phosphatase
UniProt Protein Name:Phosphoserine phosphatase
UniProt Synonym Protein Names:L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase
Protein Family:Psp operon transcriptional activator
UniProt Gene Name:PSPH  
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