Human PSAT1 Recombinant Protein (RPPB2195)
- SKU:
- RPPB2195
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- PSAT1
- Synonyms:
- Phosphoserine aminotransferase
- Phosphohydroxythreonine aminotransferase
- PSAT
- PSAT1
- Source:
- Escherichia Coli
- Uniprot:
- Q9Y617
Description
| Product Name: | Human PSAT1 Recombinant Protein |
| Product Code: | RPPB2195 |
| Size: | 20µg |
| Species: | Human |
| Target: | PSAT1 |
| Synonyms: | Phosphoserine aminotransferase, Phosphohydroxythreonine aminotransferase, PSAT, PSAT1, PSA, EPIP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The PSAT1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMDAPRQ VVNFGPGPAK LPHSVLLEIQ KELLDYKGVG ISVLEMSHRS SDFAKIINNT ENLVRELLAV PDNYKVIFLQ GGGCGQFSAV PLNLIGLKAG RCADYVVTGA WSAKAAEEAK KFGTINIVHP KLGSYTKIPD PSTWNLNPDA SYVYYCANET VHGVEFDFIP DVKGAVLVCD MSSNFLSKPV DVSKFGVIFA GAQKNVGSAG VTVVIVRDDL LGFALRECPS VLEYKVQAGN SSLYNTPPCF SIYVMGLVLE WIKNNGGAAA MEKLSSIKSQ TIYEIIDNSQ GFYVCPVEPQ NRSKMNIPFR IGNAKGDDAL EKRFLDKALE LNMLSLKGHR SVGGIRASLY NAVTIEDVQK LAAFMKKFLE MHQL |
Phosphoserine aminotransferase (PSAT1) catalyzes the conversion of 3-phosphohydroxypyruvate into 3-phosphoserine which is dephosphorylated consequently by phosphoserine phosphatase to form L-serine. PSAT1 is probably a phosphoserine aminotransferase, based on similarity to proteins in mouse, rabbit, and Drosophila. PSAT1 is expressed at high levels in the brain, liver, kidney and pancreas, and very weakly expressed in the thymus, prostate, testis and colon. Defects in the PSAT1 gene are the cause of phosphoserine aminotransferase deficiency (PSATD). PSATD is distinguished biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.
PSAT1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 394 amino acids (1-370) and having a molecular mass of 42.9kDa.PSAT1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. |
| NCBI Summary: | This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, and 8. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9Y617 |
| NCBI GenInfo Identifier: | 20141815 |
| NCBI Gene ID: | 29968 |
| NCBI Accession: | Q9Y617.2 |
| UniProt Secondary Accession: | Q9Y617,Q5T7G5, Q5T7G6, Q96AW2, Q9BQ12, |
| UniProt Related Accession: | Q9Y617 |
| Molecular Weight: | 41 kDa |
| NCBI Full Name: | Phosphoserine aminotransferase |
| NCBI Synonym Full Names: | phosphoserine aminotransferase 1 |
| NCBI Official Symbol: | PSAT1 |
| NCBI Official Synonym Symbols: | PSA; EPIP; NLS2; PSAT; PSATD |
| NCBI Protein Information: | phosphoserine aminotransferase |
| UniProt Protein Name: | Phosphoserine aminotransferase |
| UniProt Synonym Protein Names: | Phosphohydroxythreonine aminotransferase; PSAT |
| Protein Family: | Phosphoserine aminotransferase |
| UniProt Gene Name: | PSAT1 |
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