Human PRTN3 Recombinant Protein (RPPB2296)
- SKU:
- RPPB2296
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- PRTN3
- Synonyms:
- AGP7
- P29
- PR-3
- ACPA
- Source:
- Native
- Uniprot:
- P24158
Description
| Product Name: | Human PRTN3 Recombinant Protein |
| Product Code: | RPPB2296 |
| Size: | 10µg |
| Species: | Human |
| Target: | PRTN3 |
| Synonyms: | AGP7, P29, PR-3, ACPA, C-ANCA, MBT, MBN, Leukocyte proteinase 3, Neutrophil proteinase 4, Wegener granulomatosis autoantigen, Azurophil granule protein 7, myeloblastin, Serine proteinase neutrophil. |
| Source: | Native |
| Formulation: | PRTN3 is supplied in 20mM Sodium Phosphate pH-6.2, 300mM NaCl, and 0.02% Lubrol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% in the sum of different glycosylation isoforms according to following section as determined by SDS-PAGE and capillary electrophoresis. |
PRTN3 is a polymorphonuclear leukocyte serine protease which degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema once managed by tracheal insufflation to hamsters.
PRTN3 is a natural antigen having a molecular mass of 25kDa. PRTN3 is isolated from human peripheral blood leukocytes.
| UniProt Protein Function: | PRTN3: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. Belongs to the peptidase S1 family. Elastase subfamily. |
| UniProt Protein Details: | Protein type:EC 3.4.21.76; Cell cycle regulation; Protease Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytosol; extracellular matrix; extracellular space; plasma membrane Molecular Function:enzyme binding; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: blood coagulation; negative regulation of phagocytosis; positive regulation of cell proliferation |
| UniProt Code: | P24158 |
| NCBI GenInfo Identifier: | 6174926 |
| NCBI Gene ID: | 5657 |
| NCBI Accession: | P24158.3 |
| UniProt Secondary Accession: | P24158,P15637, P18078, Q4VB08, Q4VB09, Q6LBM7, Q6LBN2 Q9UD25, Q9UQD8, |
| UniProt Related Accession: | P24158 |
| Molecular Weight: | 27,807 Da |
| NCBI Full Name: | Myeloblastin |
| NCBI Synonym Full Names: | proteinase 3 |
| NCBI Official Symbol: | PRTN3 |
| NCBI Official Synonym Symbols: | MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA |
| NCBI Protein Information: | myeloblastin |
| UniProt Protein Name: | Myeloblastin |
| UniProt Synonym Protein Names: | AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen |
| Protein Family: | Myeloblastin |
| UniProt Gene Name: | PRTN3 |
| UniProt Entry Name: | PRTN3_HUMAN |
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