Human PRND Recombinant Protein (RPPB4292)

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SKU:
RPPB4292
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
PRND
Synonyms:
Prion protein 2
Synonyms:
DOPPEL
Synonyms:
DPL
Synonyms:
PrPL
Source:
Escherichia Coli
Uniprot:
Q9UKY0
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Description

Product Name:Human PRND Recombinant Protein
Product Code:RPPB4292
Size:10µg
Species:Human
Target:PRND
Synonyms:Prion protein 2, DOPPEL, DPL, PrPL.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PRND protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 0.2M NaCl, 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSRGIKHRI KWNRKALPST AQITEAQVAE NRPGAFIKQG RKLDIDFGAE GNRYYEANYW QFPDGIHYNG CSEANVTKEA FVTGCINATQ AANQGEFQKP DNKLHQQVLW RLVQELCSLK HCEFWLERG

PRND is a membrane glycosylphosphatidylinositol-anchored glycoprotein which exists mainly in testis. PRND is expressed during embryogenesis, although in the central nervous system it is expressed minimally .Mutations in PRND may cause neurological disorders. PRND located on chromosome 20, about 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally analogous.

PRND Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 149 amino acids (27-152a.a) and having a molecular mass of 58.5kDa. PRND is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PRND: This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: plasma membrane

Biological Process: protein homooligomerization

NCBI Summary:This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UKY0
NCBI GenInfo Identifier:68067934
NCBI Gene ID:23627
NCBI Accession:Q9UKY0.2
UniProt Secondary Accession:Q9UKY0,Q9H311, Q9H312, Q9NTM4, A7U7M5,
UniProt Related Accession:Q9UKY0
Molecular Weight:176
NCBI Full Name:Prion-like protein doppel
NCBI Synonym Full Names:prion protein 2 (dublet)
NCBI Official Symbol:PRND  
NCBI Official Synonym Symbols:DPL; PrPLP; DOPPEL; dJ1068H6.4  
NCBI Protein Information:prion-like protein doppel; prion gene complex, downstream
UniProt Protein Name:Prion-like protein doppel
UniProt Synonym Protein Names:PrPLP; Prion protein 2
Protein Family:Prion-like protein doppel
UniProt Gene Name:PRND  
UniProt Entry Name:PRND_HUMAN
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