Human PPP1R3B Recombinant Protein (RPPB4285)

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SKU:
RPPB4285
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
PPP1R3B
Synonyms:
Protein phosphatase 1 regulatory subunit 3B
Synonyms:
Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
Synonyms:
Protein phosphatase 1 regulatory subunit 4
Synonyms:
PP1 subunit R4
Source:
Escherichia Coli
Uniprot:
Q86XI6
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Description

Product Name:Human PPP1R3B Recombinant Protein
Product Code:RPPB4285
Size:20µg
Species:Human
Target:PPP1R3B
Synonyms:Protein phosphatase 1 regulatory subunit 3B, Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL, Protein phosphatase 1 regulatory subunit 4, PP1 subunit R4, Protein phosphatase 1 subunit GL, PTG, PPP1R4, PPP1R3B, Protein Phosphatase 1, Regulatory Subunit 3B, GL.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The PPP1R3B solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMMAVDIE YRYNCMAPSL RQERFAFKIS PKPSKPLRPC IQLSSKNEAS GMVAPAVQEK KVKKRVSFAD NQGLALTMVK VFSEFDDPLD MPFNITELLD NIVSLTTAES ESFVLDFSQP SADYLDFRNR LQADHVCLEN CVLKDKAIAG TVKVQNLAFE KTVKIRMTFD TWKSYTDFPC QYVKDTYAGS DRDTFSFDIS LPEKIQSYER MEFAVYYECN GQTYWDSNRG KNYRIIRAEL KSTQGMTKPH SGPDLGISFD QFGSPRCSYG LFPEWPSYLG YEKLGPYY

Protein Phosphatase 1, Regulatory Subunit 3B (PPP1R3B) is the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. PPP1R3B, which is expressed both in liver and in skeletal muscle tissue, regulates glycogen synthesis in these tissues. PPP1R3B is involved in type 2 diabetes and maturity-onset diabetes of the young.

PPP1R3B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 308 amino acids (1-285) and having a molecular mass of 35.1 kDa.PPP1R3B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PPP1R3B: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
UniProt Protein Details:

Protein type:Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 8p23.1

Biological Process: regulation of glycogen catabolic process

NCBI Summary:This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]
UniProt Code:Q86XI6
NCBI GenInfo Identifier:74727837
NCBI Gene ID:79660
NCBI Accession:Q86XI6.1
UniProt Secondary Accession:Q86XI6,Q9H812, B3KTV3,
UniProt Related Accession:Q86XI6
Molecular Weight:32,695 Da
NCBI Full Name:Protein phosphatase 1 regulatory subunit 3B
NCBI Synonym Full Names:protein phosphatase 1 regulatory subunit 3B
NCBI Official Symbol:PPP1R3B  
NCBI Official Synonym Symbols:GL; PTG; PPP1R4  
NCBI Protein Information:protein phosphatase 1 regulatory subunit 3B
UniProt Protein Name:Protein phosphatase 1 regulatory subunit 3B
UniProt Synonym Protein Names:Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL; Protein phosphatase 1 regulatory subunit 4; PP1 subunit R4; Protein phosphatase 1 subunit GL; PTG
Protein Family:Protein phosphatase 1 regulatory
UniProt Gene Name:PPP1R3B  
UniProt Entry Name:PPR3B_HUMAN
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