Human PPP1R1A Recombinant Protein (RPPB2166)
- SKU:
- RPPB2166
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- PPP1R1A
- Synonyms:
- IPP1
- IPP-1
- I-1
- PPP1R1A
- Source:
- Escherichia Coli
- Uniprot:
- Q13522
Description
| Product Name: | Human PPP1R1A Recombinant Protein |
| Product Code: | RPPB2166 |
| Size: | 20µg |
| Species: | Human |
| Target: | PPP1R1A |
| Synonyms: | IPP1, IPP-1, I-1, PPP1R1A, PPI-1, Protein Phosphatase Inhibitor-1, Protein phosphatase 1 regulatory subunit 1A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The PPP1R1A solution contains 50mM Tris pH-8, 0.1mM PMSF, 1mM EDTA, 1mM DTT & 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MEQDNSPRKI QFTVPLLEPH LDPEAAEQIR RRRPTPATLV LTSDQSSPEI DEDRIPNPHL KSTLAMSPRQ RKKMTRITPT MKELQMMVEH HLGQQQQGEE PEGAAESTGT QESRPPGIPD TEVESRLGTS GTAKKTAECI PKTHERGSKE PSTKEPSTHI PPLDSKGANS VLEHHHHHH |
PPP1R1A is an inhibitor of protein-phosphatase 1. IPP-1 protein plays important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP elevate IPP-1 activity. PPP1R1A activation caused cAMP to control over proteins that are not directly phosphorylated by PKA following a rise in intracellular calcium, IPP-1 is inactivated by calcineurin (PP2B). Multiple domains in IPP-1 target cellular PP1 complexes. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation.
PPP1R1A Human Recombinant fused with His tag at C-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 179 amino acids and having a molecular mass of 20 kDa.The PPP1R1A is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. |
| UniProt Code: | Q13522 |
| NCBI GenInfo Identifier: | 155030238 |
| NCBI Gene ID: | 5502 |
| NCBI Accession: | NP_006732.3 |
| UniProt Secondary Accession: | Q13522,Q6IB01, Q8TBJ2, Q8WWV2, |
| UniProt Related Accession: | Q13522 |
| Molecular Weight: | 18 |
| NCBI Full Name: | protein phosphatase 1 regulatory subunit 1A |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory inhibitor subunit 1A |
| NCBI Official Symbol: | PPP1R1A |
| NCBI Official Synonym Symbols: | I1; IPP1 |
| NCBI Protein Information: | protein phosphatase 1 regulatory subunit 1A |
| UniProt Protein Name: | Protein phosphatase 1 regulatory subunit 1A |
| UniProt Synonym Protein Names: | Protein phosphatase inhibitor 1; I-1; IPP-1 |
| UniProt Gene Name: | PPP1R1A |
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