Human PPA2 Recombinant Protein (RPPB2150)
- SKU:
- RPPB2150
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- PPA2
- Synonyms:
- PPA2
- Pyrophosphatase-2
- Inorganic pyrophosphatase 2
- mitochondrial
- Source:
- Escherichia Coli
- Uniprot:
- Q9H2U2
Description
| Product Name: | Human PPA2 Recombinant Protein |
| Product Code: | RPPB2150 |
| Size: | 20µg |
| Species: | Human |
| Target: | PPA2 |
| Synonyms: | PPA2, Pyrophosphatase-2, Inorganic pyrophosphatase 2, mitochondrial, PPase 2, Pyrophosphatase SID6-306, Pyrophosphate phospho-hydrolase 2, HSPC124, Pyrophosphatase (inorganic) 2, SID6-306, Inorganic pyrophosphatase 2, mitochondrial isoform 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | PPA2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol, 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSALYHTEE RGQPCSQNYR LFFKNVTGHY ISPFHDIPLK VNSKEENGIP MKKARNDEYE NLFNMIVEIP RWTNAKMEIA TKEPMNPIKQ YVKDGKLRYV ANIFPYKGYI WNYGTLPQTW EDPHEKDKST NCFGDNDPID VCEIGSKILS CGEVIHVKIL GILALIDEGE TDWKLIAINA NDPEASKFHD IDDVKKFKPG YLEATLNWFR LYKVPDGKPE NQFAFNGEFK NKAFALEVIK STHQCWKALL MKKCNGGAIN CTNVQISDSP FRCTQEEARS LVESVSSSPN KESNEEEQVW HFLGK |
PPA2 shares great imagination with members of the inorganic pyrophosphatase (PPase) family. PPA2 is localized to the mitochondrion and owns the signature sequence necessary for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is vital for the phosphate metabolism of cells.
PPA2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 325 amino acids (33-334 a.a) and having a molecular mass of 37.1kDa.PPA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PPA2: is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Mitochondrial; Hydrolase; EC 3.6.1.1; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 4q25 Cellular Component: mitochondrial matrix Molecular Function:inorganic diphosphatase activity; magnesium ion binding; protein serine/threonine phosphatase activity Biological Process: tRNA aminoacylation for protein translation; dephosphorylation; gene expression |
| NCBI Summary: | The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H2U2 |
| NCBI GenInfo Identifier: | 77812678 |
| NCBI Gene ID: | 27068 |
| NCBI Accession: | NP_008834.3 |
| UniProt Secondary Accession: | Q9H2U2,Q4W5E9, Q6PG51, Q8TBW0, Q96E55, Q9H0T0, Q9NX37 Q9P033, Q9ULX0, B4DLP7, F8WDN9, I6L9B6, |
| UniProt Related Accession: | Q9H2U2 |
| Molecular Weight: | 25,992 Da |
| NCBI Full Name: | inorganic pyrophosphatase 2, mitochondrial isoform 2 |
| NCBI Synonym Full Names: | pyrophosphatase (inorganic) 2 |
| NCBI Official Symbol: | PPA2 |
| NCBI Official Synonym Symbols: | HSPC124; SID6-306 |
| NCBI Protein Information: | inorganic pyrophosphatase 2, mitochondrial |
| UniProt Protein Name: | Inorganic pyrophosphatase 2, mitochondrial |
| UniProt Synonym Protein Names: | Pyrophosphatase SID6-306; Pyrophosphate phospho-hydrolase 2; PPase 2 |
| Protein Family: | Soluble inorganic pyrophosphatase |
| UniProt Gene Name: | PPA2 |
| UniProt Entry Name: | IPYR2_HUMAN |
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