Human PKNOX1 Recombinant Protein (RPPB4255)

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SKU:
RPPB4255
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
PKNOX1
Synonyms:
pkonx1c
Synonyms:
PREP1
Synonyms:
Homeobox protein PKNOX1
Synonyms:
Homeobox protein PREP-1
Source:
Escherichia Coli
Uniprot:
P55347
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Description

Product Name:Human PKNOX1 Recombinant Protein
Product Code:RPPB4255
Size:5µg
Species:Human
Target:PKNOX1
Synonyms:pkonx1c, PREP1, Homeobox protein PKNOX1, Homeobox protein PREP-1, PBX/knotted homeobox 1, PKNOX1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PKNOX1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSEPDAEGV SPPPVESQTP MDVDKQAIYR HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ EKEGKPFFCE DPETDNLMVK AIQVLRIHLL ELEKVNELCK DFCSRYIACL KTKMNSETLL SGEPGSPYSP VQSQQIQSAI TGTISPQGIV VPASALQQGN VAMATVAGGT VYQPVTVVTP QGQVVTQTLS PGTIRIQNSQ LQLQLNQDLS ILHQDDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKTAQNR PVQRFWPDSI ASGVAQPPPS ELTMSEGAVV TITTPVNMNV DSLQSLSSDG ATLAVQQVMM AGQSEDESVD STEEDAGALA PAHISGLVLE NSDSLQ

PBX/Knotted 1 Homeobox 1 (PKNOX1) is a DNA-binding factor which takes part in the regulation of the transcriptional activity of AP-1 containing promoters. PKNOX1, which is also known as UEF3, PRP-1 and p64, is a Hmeobox protein. PKNOX1 forms stable complexes containing PBX proteins which synergize with AP-1 binding factors.

PKNOX1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 456 amino acids (1-436 a.a) and having a molecular mass of 49.7kDa. PKNOX1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:PKNOX1: Belongs to the TALE/MEIS homeobox family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 21q22.3

Molecular Function:transcription factor activity

UniProt Code:P55347
NCBI GenInfo Identifier:115311619
NCBI Gene ID:5316
NCBI Accession:P55347.3
UniProt Secondary Accession:P55347,O00528, Q8IWT7,
UniProt Related Accession:P55347
Molecular Weight:44,629 Da
NCBI Full Name:Homeobox protein PKNOX1
NCBI Synonym Full Names:PBX/knotted 1 homeobox 1
NCBI Official Symbol:PKNOX1  
NCBI Official Synonym Symbols:PREP1; pkonx1c  
NCBI Protein Information:homeobox protein PKNOX1
UniProt Protein Name:Homeobox protein PKNOX1
UniProt Synonym Protein Names:Homeobox protein PREP-1; PBX/knotted homeobox 1
Protein Family:Homeobox protein
UniProt Gene Name:PKNOX1  
UniProt Entry Name:PKNX1_HUMAN
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