Human PKIB Recombinant Protein (RPPB2619)

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SKU:
RPPB2619
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
PKIB
Synonyms:
cAMP-dependent protein kinase inhibitor beta
Synonyms:
PKI-beta
Synonyms:
PKIB
Synonyms:
PRKACN2
Source:
Escherichia Coli
Uniprot:
Q9C010
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Description

Product Name:Human PKIB Recombinant Protein
Product Code:RPPB2619
Size:25µg
Species:Human
Target:PKIB
Synonyms:cAMP-dependent protein kinase inhibitor beta, PKI-beta, PKIB, PRKACN2, FLJ23817.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:PKIB solution (1mg/ml) 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MRTDSSKMTD VESGVANFAS SARAGRRNAL PDIQSSAATD GTSDLPLKLE ALSVKEDAKE KDEKTTQDQL EKPQNEEK

cAMP-dependent protein kinase inhibitor beta (PKIB) belongs to the cAMP-dependent protein kinase inhibitor family. PKIB may interact with the catalytic subunit of cAMP-dependent protein kinase and function as a competitive inhibitor.

PKIB Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 98 amino acids (1-78) and having a molecular mass of 10.6kDa (Molecular size on SDS-PAGE will appear higher). PKIB is fused to a 20 aa His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:PKIB: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family.
UniProt Protein Details:

Protein type:Protein kinase, regulatory subunit; Inhibitor

Chromosomal Location of Human Ortholog: 6q22.31

Cellular Component: cytoplasm; nucleus

Molecular Function:cAMP-dependent protein kinase inhibitor activity

NCBI Summary:This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
UniProt Code:Q9C010
NCBI GenInfo Identifier:17378640
NCBI Gene ID:5570
NCBI Accession:Q9C010.1
UniProt Secondary Accession:Q9C010,Q567T9, Q5T0Z7, B2RCK2,
UniProt Related Accession:Q9C010
Molecular Weight:9,237 Da
NCBI Full Name:cAMP-dependent protein kinase inhibitor beta
NCBI Synonym Full Names:protein kinase (cAMP-dependent, catalytic) inhibitor beta
NCBI Official Symbol:PKIB  
NCBI Official Synonym Symbols:PRKACN2  
NCBI Protein Information:cAMP-dependent protein kinase inhibitor beta; PKI-beta; cAMP-dependent protein kinase inhibitor 2
UniProt Protein Name:cAMP-dependent protein kinase inhibitor beta
Protein Family:cAMP-dependent protein kinase
UniProt Gene Name:PKIB  
UniProt Entry Name:IPKB_HUMAN
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