Human PIM2 Recombinant Protein (RPPB4250)

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SKU:
RPPB4250
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
PIM2
Synonyms:
Pim-2 oncogene
Synonyms:
Serine/threonine-protein kinase pim-2
Synonyms:
Pim-2h
Synonyms:
PIM2
Source:
Escherichia Coli
Uniprot:
Q9P1W9
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Description

Product Name:Human PIM2 Recombinant Protein
Product Code:RPPB4250
Size:10µg
Species:Human
Target:PIM2
Synonyms:Pim-2 oncogene, Serine/threonine-protein kinase pim-2, Pim-2h, PIM2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:PIM2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMLTKPLQ GPPAPPGTPT PPPGGKDREA FEAEYRLGPL LGKGGFGTVF AGHRLTDRLQ VAIKVIPRNR VLGWSPLSDS VTCPLEVALL WKVGAGGGHP GVIRLLDWFE TQEGFMLVLE RPLPAQDLFD YITEKGPLGE GPSRCFFGQV VAAIQHCHSR GVVHRDIKDE NILIDLRRGC AKLIDFGSGA LLHDEPYTDF DGTRVYSPPE WISRHQYHAL PATVWSLGIL LYDMVCGDIP FERDQEILEA ELHFPAHVSP DCCALIRRCL APKPSSRPSL EEILLDPWMQ TPAEDVPLNP SKGGPAPLAW SLLP

PIM2 is a serine/threonine protein kinase which is a part of the CAMK family. PIM2 is expressed in various tissues mainly in spleen, thymus, testis and small intestine. PIM2 is implicated in tumor phenotypes and participates in the formation and preservation of Long-Term Potentiation (LTP). PIM2 is also involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

PIM2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 334 amino acids (1-311 a.a) and having a molecular mass of 36.6kDa. PIM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Pim2: a Ca(2 )/calmodulin-dependent protein kinase of the PIM family. Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells.
UniProt Protein Details:

Protein type:Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Oncoprotein; EC 2.7.11.1; CAMK group; PIM family

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: cytoplasm

Molecular Function:protein binding; protein serine/threonine kinase activity

Biological Process: cell proliferation; G1/S transition of mitotic cell cycle; male meiosis; negative regulation of apoptosis; negative regulation of cell proliferation; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein stabilization; regulation of mitotic cell cycle; response to virus

NCBI Summary:This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]
UniProt Code:Q9P1W9
NCBI GenInfo Identifier:20139243
NCBI Gene ID:11040
NCBI Accession:Q9P1W9.1
UniProt Secondary Accession:Q9P1W9,Q99739, A8K4G6,
UniProt Related Accession:Q9P1W9
Molecular Weight:34,190 Da
NCBI Full Name:Serine/threonine-protein kinase pim-2
NCBI Synonym Full Names:Pim-2 proto-oncogene, serine/threonine kinase
NCBI Official Symbol:PIM2  
NCBI Protein Information:serine/threonine-protein kinase pim-2
UniProt Protein Name:Serine/threonine-protein kinase pim-2
UniProt Synonym Protein Names:Pim-2h
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:PIM2  
UniProt Entry Name:PIM2_HUMAN
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